Sökning: "gene expression profiling"

Visar resultat 21 - 25 av 265 avhandlingar innehållade orden gene expression profiling.

  1. 21. Estrogen receptor alpha and beta in breast cancer - gene expression profiles and clinical implications

    Författare :Sofia Gruvberger; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; oncology; cancerology; Cytologi; onkologi; cancer; Cytology; artificial neural networks; gene expression profiling; microarray; tamoxifen; adjuvant endocrine therapy; ER; estrogen receptor beta; Breast cancer; estrogen receptor alpha; Clinical biology;

    Sammanfattning : Breast cancer is the most common malignancy in women in the Western world with about 10% of women developing breast cancer during their lifetime, of which one third will eventually succumb to the metastatic form of the disease. Breast cancer arises from the epithelial cells of the breast mammary gland, but the mechanisms involved in tumor initiation, progression, and metastasis are still not fully understood. LÄS MER

  3. 22. Epigenetic and Phenotypic Profiling of Urothelial Carcinoma

    Författare :Mattias Aine; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epigenetics; DNA methylation; gene expression; urothelial carcinoma; bladder cancer;

    Sammanfattning : Precise spatial and temporal regulation of gene expression programs is a prerequisite for multicellular life. Since the discovery of DNA as the carrier of genetic information, a key question in biology has been how these hard coded instructions are read and regulated to maintain cellular and organismal homeostasis. LÄS MER

  4. 23. Gene expression profiling in molecular studies of hormone actions

    Författare :Nina Ståhlberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Although the link between hormones and their physiological effects have been known for a long time, large pieces are still missing in our understanding of how these extracellular signals induce their effects at the cellular level. Signal transduction studies have gathered plenty of information about hormone signaling, but the complex network of interactions between different hormones, signaling pathways and cell types is still not completely understood. LÄS MER

  5. 24. Microarray gene expression in immunological conditions

    Författare :Abdulkareem Musa Heevy Al-Chaqmaqchi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The use of microarray techniques for gene expression analysis provides a global view of the transcriptional activity in a biological sample. In this thesis two conditions accompanied by disturbance in the immune system are addressed following the changes in gene expression. LÄS MER

  7. 25. Genomic profiling and gene-gene interaction in rheumatoid arthritis

    Författare :Klementy Shchetynsky; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Complex disease is characterized by the interplay of multiple genetic and environmental factors. Rheumatoid arthritis (RA) is a complex autoimmune disease with a pronounced genetic component, mainly due to HLA-DRB1 gene, but also a multitude of loci outside the HLA region. LÄS MER