Sökning: "fusion oncogene"
Visar resultat 6 - 10 av 20 avhandlingar innehållade orden fusion oncogene.
6. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma and other cartilage tumors
Sammanfattning : .... LÄS MER
7. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms
Sammanfattning : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. LÄS MER
8. Molecular studies of genetic changes in myxoid and round cell liposarcoma
Sammanfattning : Chromosomal translocations commonly result in the production of fusion genes and the fusion genes are often tumor-type specific. In myxoid and round cell liposarcomas (MLS/RCLS), almost 95% of the cases carry a t(12;16)(q13;p11). In the remaining 5% of the MLS/RCLS tumors, another translocation and fusion gene can be found, i.e. LÄS MER
9. The role of fusion oncogenes and cancer stem cells in myxoid liposarcoma
Sammanfattning : Myxoid liposarcoma (MLS) is characterised by the FUS-DDIT3, or the less common EWSR1-DDIT3 fusion oncogene and is the second most common type of liposarcoma. The fusion oncogenes encode chimeric transcription factors that are causal factors in tumourigenesis however, their functions are poorly known. LÄS MER
10. Growth factor pathways in human cancer : functional and therapeutic implications
Sammanfattning : The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric proteins with tumorigenic functions etc. However, in the selection leading to cancer in somatic tissues it is likely that the cancer cells make use of the normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. LÄS MER