Sökning: "fusion oncogene"
Visar resultat 1 - 5 av 20 avhandlingar innehållade orden fusion oncogene.
1. Transcriptomic and functional studies of fusion oncogene-driven salivary gland tumors
Sammanfattning : Fusion genes are potent oncogenic drivers resulting from exchange of regulatory/coding sequences between two genes. They were originally identified in leukemias but are now recognized as key oncogenic events also in many solid tumors, including salivary gland tumors (SGTs). LÄS MER
2. Studies of Fusion Oncogenes and Genomic Imbalances in Human Tumors
Sammanfattning : Cancer is a genetic disease caused by mutations and chromosome rearrangements affecting oncogenes and tumor suppressor genes in particular. Molecular analyses of recurrent translocations in hematological disorders, as well as in certain solid tumor types, have shown that they frequently result in fusion oncogenes. LÄS MER
3. Studies of PLAG1 and HMGIC fusion oncogenes in human tumors
Sammanfattning : .... LÄS MER
4. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3
Sammanfattning : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. LÄS MER
5. Anaplastic Lymphoma Kinase mutations and downstream signalling
Sammanfattning : The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. LÄS MER