Sökning: "spectral karyotyping SKY"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden spectral karyotyping SKY.

  1. 1. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma and other cartilage tumors

    Författare :Helene Sjögren; Göteborgs universitet; []
    Nyckelord :Extraskeletal myxoid chondrosarcoma; chondroblastoma; chondrosarcoma; spectral karyotyping SKY ; chromosome translocation; fusion oncogene; cDNA microarray; TEC; EWS; TAF2N; TCF12;

    Sammanfattning : .... LÄS MER

  3. 2. Molecular studies of acute myeloid leukemia and the telomerase reverse transcriptase gene

    Författare :Charlotta Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aacute myeloid leukaemia; telomerase hTERT; cancer cytogenetics; spectral karyotyping; gene expression profiling;

    Sammanfattning : Multiple chromosome rearrangements (MCRs) are detected in approximately 10% of patients with acute myeloid leukemia (AML), and are associated with an adverse prognosis. Comprehensive analysis of the chromosome rearrangements in these complex karyotypes has previously been hampered by the limitations of conventional cytogenetic techniques such as G-banding. LÄS MER

  4. 3. Molecular cytogenetic investigations of chromosomal abnormalities in prostate and urinary bladder cancers

    Författare :Yi Pan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :prostate cancer; bladder cancer; FISH; SKY;

    Sammanfattning : Tumorigenesis is suggested to be caused by base pair mutations and chromosomal abnormalities leading to inactivation of tumor suppressor genes an activation of oncogenes. However, still it is not clear for the vast majority of these changes how they contribute to the tumorigenesis of the prostate and bladder cancers. LÄS MER

  5. 4. Characterisation of chromosomal aberrations in childhood leukaemia

    Författare :Ann Nordgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Chromosome aberrations; SKY; interphase-FISH; Childhood ALL;

    Sammanfattning : Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood, accounting for approximately 25% of all paediatric malignancies. Based on clinical risk criteria and modem laboratory investigations including immunophenotyping, cytogenetics, and molecular genetics, patients can be divided into prognostic groups and assigned to risk- adjusted treatment protocols. LÄS MER

  7. 5. Molecular genetic aspects of renal cell carcinoma development

    Författare :Andrei Alimov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Kidney tumor; RCC; LOH; CGH; SKY; PTEN; chromosome 3p; chromosome 10q; chromosome 14q;

    Sammanfattning : Renal cell carcinoma (RCC) is the most common tumor of the renal parenchyma. The aim of this study was to further characterize known as well as new genetic abnormalities in a clinical material of RCC, as well as in established cell lines to gain more information about etiological and progression factors. LÄS MER