Sökning: "CRTC1"
Hittade 3 avhandlingar innehållade ordet CRTC1.
1. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms
Sammanfattning : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. LÄS MER
2. Transcriptional regulation of miRNA-212 and miRNA-132 and their fine-tuning function of beta cell insulin secretion
Sammanfattning : Type 2 diabetes is characterized by hyperglycemia due to insulin resistance in the target tissue and insufficient insulin secretion from the beta cells. Finding new mechanisms and pathways involved in the regulation of insulin secretion from the pancreatic beta cells is of great importance. LÄS MER
3. Fishing for small molecules to treat diabetes, from a beta cell perspective
Sammanfattning : Maintenance of glucose homeostasis necessitates a precise control of insulin secretion. Pancreatic β cells sense fluctuation of blood glucose and secret insulin in response. However, functional β cell mass is decreased in diabetes. Here, to recover functional β cell mass, we use zebrafish as a model to perform in vivo drug discovery. LÄS MER