Sökning: "ortho- metalation"

Hittade 2 avhandlingar innehållade orden ortho- metalation.

1. 1. Reaction Between Grignard reagents and Heterocyclic N-oxides : Synthesis of Substituted Pyridines, Piperidines and Piperazines

   Författare :Hans Andersson; Fredrik Almqvist; Hans Adolfsson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Grignard reagents; pyridine N-oxide; pyrazine N-oxide; dienal-oxime; pyridine; ortho- metalation; piperidine; piperazine; asymmetric; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis describes the development of new synthetic methodologies for preparation of bioactive interesting compounds, e.g. substituted pyridines, piperidines or piparazines. Thesecompounds are synthesized from commercially available, cheap and easily prepared reagents, videlicet the reaction between Grignard reagents and heterocyclic N-oxides. LÄS MER

3. 2. Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds

   Författare :Hamid Shirani; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Heterocycles; indoles; 3- arylthio indoles; thiopyranobisindoles; dibenzothiepins; 3; 3′-dithiobisindoles; alkaloids; echinosulfone A; cyclization; ortho-metalation; McMurry coupling; sulfides; sulfones and disulfides;

   Sammanfattning : This thesis deals mainly with the synthesis of various sulfur/selenium-containing heterocyclic compounds, many of which include structural features present in several biologically active molecules, with particular emphasis on compounds of synthetic importance, such as indoles, as well as other heteroaromatic species. In the first part, an efficient procedure toward synthesis of new 3-(arylthio)indoles based on reactions of aryl Grignard reagents or lithiated heteroaromatics with protected 3,3′-dithiobisindoles is described. LÄS MER