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Visar resultat 11 - 15 av 38 avhandlingar som matchar ovanstående sökkriterier.

1. 11. Early Environment, Adolescent Alcohol Drinking and Neurobiological Responses to Drugs

   Författare :Sara Palm; Ingrid Nylander; Anne-Lie Svensson; Lundblad Martin; Giancarlo Colombo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adolescence; beta-endorphin; dopamine; dynorphin; endogenous opioids; enkephalin; high-speed chronoamperometry; housing conditions; maternal separation; multivariate concentric square field™ test; open field test; radioimmunoassay; voluntary alcohol intake; Wistar rats; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : Genes and environment interact to determine an individual’s vulnerability or resilience to several psychiatric disorders, including alcohol use disorder (AUD). Alcohol use is often initiated during adolescence and early onset drinking is associated with increased risk for later AUD. LÄS MER

3. 12. Spectroscopic studies of dynorphin neuropeptides and the amyloid beta-peptide : The consequences of biomembrane interactions

   Författare :Loïc Hugonin; Astrid Gräslund; Bernard Lebleu; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik; Biophysics; biofysik;

   Sammanfattning : Dynorphin A, dynorphin B and big dynorphin are endogenous opioid neuropeptides. They play an important role in a wide variety of physiological functions such as regulation of pain processing and memory acquisition. Such actions are generally mediated through the κ-receptors. LÄS MER

4. 13. Endogenous Opioids and Voluntary Ethanol Drinking : Consequences of Postnatal Environmental Influences in Rats

   Författare :Lisa Gustafsson; Ingrid Nylander; Erika Roman; Ryszard Przewlocki; Uppsala universitet; []
   Nyckelord :Pharmaceutical pharmacology; Maternal separation; Maternal deprivation; Handling; Isolation; Alcohol; Two-bottle model; Four-bottle model; MEAP; Dynorphin B; Nociceptin orphanin FQ; Radioimmunoassay; Farmaceutisk farmakologi;

   Sammanfattning : Genetic and environmental factors interact to determine the individual vulnerability to develop ethanol dependence. The neurobiological mechanisms underlying these processes are not fully understood. Endogenous opioid peptides have been suggested to contribute. LÄS MER

5. 14. Cocaine effects on striatal dynorphin and CART neuropeptides : association to mood disorder

   Författare :Pernilla Fagergren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cocaine; Prodynorphin; CART; Striatum; Drug abuse; Dependence; Depression; Anxiety; In situ hybridization;

   Sammanfattning : People take cocaine to elevate mood, but with repeated use and subsequent development of dependence, in paradox, a negative mood state is induced. This may be one reason for the strong comorbidity between cocaine dependence and mood disorders. A common substrate implicated in both disorders is the neurotransmitter dopamine. LÄS MER

7. 15. Intracellular signaling and cellular plasticity in a rat model of L-DOPA-induced dyskinesia

   Författare :Jenny Westin; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein synthesis; Nukleinsyror; proteinsyntes; neurofysiologi; Nucleic acids; Neurologi; neuropsykologi; L-DOPA; Dopamine; Neurology; neuropsychology; neurophysiology; Parkinson s disease;

   Sammanfattning : Parkinson's disease (PD) is a neurodegenerative disorder where the midbrain dopaminergic neurons are lost. Presently there is no cure for PD, and the most common treatment is to replace the lost dopamine pharmacologically by administration of the dopamine precursor L-DOPA. LÄS MER