Sökning: "Two-bottle model"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Two-bottle model.

1. 1. Endogenous Opioids and Voluntary Ethanol Drinking : Consequences of Postnatal Environmental Influences in Rats

   Författare :Lisa Gustafsson; Ingrid Nylander; Erika Roman; Ryszard Przewlocki; Uppsala universitet; []
   Nyckelord :Pharmaceutical pharmacology; Maternal separation; Maternal deprivation; Handling; Isolation; Alcohol; Two-bottle model; Four-bottle model; MEAP; Dynorphin B; Nociceptin orphanin FQ; Radioimmunoassay; Farmaceutisk farmakologi;

   Sammanfattning : Genetic and environmental factors interact to determine the individual vulnerability to develop ethanol dependence. The neurobiological mechanisms underlying these processes are not fully understood. Endogenous opioid peptides have been suggested to contribute. LÄS MER

3. 2. Maternal Separation in the Rat : The Short- and Long-term effects of Early-life Experience on Neuropeptides, Monoamines and Voluntary Ethanol Consumption

   Författare :Sadia Oreland; Ingird Nylander; Joram Feldon; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Early-life stress; Handling; Serotonin; Dopamine; Oxytocin; Vasopressin; Enkephalin; Dynorphin; Two-bottle free choice; Maternal deprivation; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Farmaceutisk farmakologi; Pharmaceutical Pharmacology;

   Sammanfattning : Early-life experience has profound effects on the individual’s neurobiology and behaviour later in life. The rodent animal experimental model maternal separation (MS) was used to study this more in detail. The MS model involves short and prolonged postnatal separations simulating an emotionally safe and stressful environment, respectively. LÄS MER

4. 3. Neuropeptide Receptors as Treatment Targets in Alcohol Use Disorders

   Författare :Abdul Maruf Asif Aziz; Annika Thorsell; David Engblom; Elizabeth Jerlhag; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Alcohol use disorder (AUD) is a complex disorder with multiple pathophysiological processes contributing to the initiation, progression and development of the disease state. AUD is a chronic relapsing disease with escalation of alcohol-intake over time in repeated cycles of tolerance, abstinence and relapse and hence, it is very difficult to treat. LÄS MER

5. 4. The role of the dopamine system in the ability of (-)-OSU6162 to reduce voluntary alcohol drinking and binge-eating in the rat

   Författare :Kristin Feltmann; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : BACKGROUND AND AIMS: The dopamine system is involved in the reinforcing effects of both food and alcohol and is thus a potential treatment target for alcohol use disorder (AUD) and binge-eating disorder (BED). Alcohol use disorder is characterized by difficulties to control alcohol drinking and by drinking despite adverse consequences. LÄS MER

7. 5. On regulation of hippocampal neurogenesis : roles of ethanol intake, physical activity and environment

   Författare :Elin Åberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The addiction research field struggles with the question of how long-term memories associated with addictions, which are likely to have a role in the relapse phenomenon, are formed. The work in this thesis has focused on structural adaptations and changes in plasticity genes in hippocampus, formed by both naturally awarding and drug-induced reward-seeking behaviors. LÄS MER