Sökning: "CART"

Visar resultat 1 - 5 av 31 avhandlingar innehållade ordet CART.

  1. 1. The role of CART in islet function

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Mia Abels; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cocaine- and amphetamine-regulated transcript; CART; Diabetes; T2D; Human islets; Glucagon; Insulin; Adipocyte;

    Sammanfattning : Diminished insulin secretion and dysregulated glucagon secretion are key features of type 2 diabetes (T2D). The overall aim of this thesis was to study the role of cocaine- and amphetamine-regulated transcript (CART) in islet cell function and how CART regulates glucose homeostasis. LÄS MER

  2. 2. Ghrelin and CART. Two new islet peptides. Expression, regulation and function

    Detta är en avhandling från Faculty of Medicine, Lund University

    Författare :Nils Wierup; Lund University.; Lunds universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endokrinologi; sekretion; diabetologi; Endocrinology; secreting systems; diabetology; histology; endocrinology; islets; CART; Ghrelin cells; insulin secretion; type-2 diabetes; Ghrelin;

    Sammanfattning : Until recently, the islets of Langerhans were thought to harbour four main cell types characterised with respect to principal hormone product. Here we show that the novel hormone ghrelin is expressed in a fifth islet cell type, the islet ghrelin cell, in humans and rodents. LÄS MER

  3. 3. Hirschsprung´s Disease & Gastroesophageal Reflux. Aspects on Two Gastrointestinal Motility Disorders in Childhood

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Anna Gunnarsdottir; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GERD; Gastroesophageal Reflux; Duhamel pull-through; TERPT; Quality of Life; ENS; CART; Hirschsprung´s Disease; GER; pH-monitoring; Wireless; BRAVO;

    Sammanfattning : Gastrointestinal motility disorders are common in childhood and in this thesis we look at two of them, i.e. Hirschsprung´s Disease (HD) and gastroesophageal reflux disease (GERD) in five different studies. LÄS MER

  4. 4. New perspectives on pathology in Huntington's disease - characterization of hypothalamic changes

    Detta är en avhandling från Translational Neuroendocrinology

    Författare :Sanaz Gabery; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; huntingtin; hypothalamus; oxytocin; vasopressin; orexin; CART; neuroendocrinology; MRI; 3 Tesla; volymetric analysis;

    Sammanfattning : Huntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. LÄS MER

  5. 5. Cocaine effects on striatal dynorphin and CART neuropeptides : Association to mood disorder

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Författare :Pernilla Fagergren; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cocaine; Prodynorphin; CART; Striatum; Drug abuse; Dependence; Depression; Anxiety; In situ hybridization;

    Sammanfattning : People take cocaine to elevate mood, but with repeated use and subsequent development of dependence, in paradox, a negative mood state is induced. This may be one reason for the strong comorbidity between cocaine dependence and mood disorders. A common substrate implicated in both disorders is the neurotransmitter dopamine. LÄS MER