Sökning: "dsRNA"

Visar resultat 11 - 15 av 28 avhandlingar innehållade ordet dsRNA.

  1. 11. Systemic and local regulation of experimental arthritis by IFN-α, dendritic cells and uridine

    Författare :Sudeep Chenna Narendra; Mattias Magnusson; Srinivas Uppugunduri; Alf Kastbom; Natacha Bessis; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In this thesis, we have studied the immunological processes of joint inflammation that may be targets for future treatment of patients with arthritis. We focus on the immune-modulating properties of interferon-α (IFN-α) and uridine in experimental arthritis. LÄS MER

  3. 12. Anti-parasitic and anti-viral immune responses in insects

    Författare :Olle Terenius; Ingrid Faye; Kenneth Söderhäll; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hemolin; Hyalophora cecropia; Antheraea pernyi; Drosophila melanogaster; anti-viral; anti-parasitic; rna interference; microarray; innate immunity; Genetics; Genetik;

    Sammanfattning : Insects encounter many microorganisms in nature and to survive they have developed counter measures against the invading pathogens. In Drosophila melanogaster research on insect immunity has mainly been focused on infections by bacteria and fungi. LÄS MER

  4. 13. Regulation and Function of RNA Editing in the Mammalian Brain

    Författare :Chammiran Daniel; Marie Öhman; Joshua Rosenthal; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA editing; ADAR; GABAA receptor; Gabra-3; Molecular Biology; molekylärbiologi;

    Sammanfattning : Adenosine (A) to inosine (I) RNA editing is a widespread post-transcriptional mechanism in eukaryotes that increases the protein diversity. Adenosine deaminases acting on RNA (ADARs) are the enzymes that catalyze this conversion. LÄS MER

  5. 14. Enterovirus Infections of β-Cells : A Mechanism of Induction of Type 1 Diabetes?

    Författare :Anna-Karin Berg; Gun Frisk; Torsten Tuvemo; Arne Andersson; Merja Roivainen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; enterovirus; type 1 diabetes; β-cells; human pancreatic islets; picornavirus; chemokines; nitric oxide; Pediatrik; Paediatric medicine; Pediatrisk medicin;

    Sammanfattning : The process of β-cell destruction that leads to type 1 diabetes (T1D) is incompletely understood and it is believed to be a result of both genetic and environmental factors. Enterovirus (EV) infections of the β-cells have been proposed to be involved, however, the effects of EV infections on human β-cells have been little investigated. LÄS MER

  7. 15. Viral vectors, in innate and adaptive immunity

    Författare :Tanja I Näslund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Recombinant viral vectors and DNA vectors induce strong immune responses in animal models. However, in clinical trials, the generation of immune responses is less robust, suggesting that further optimization and a deeper understanding of nucleic acid-based vaccines are required. LÄS MER