Sökning: "enterovirus"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet enterovirus.

  1. 1. Enterovirus Infections of β-Cells : A Mechanism of Induction of Type 1 Diabetes?

    Författare :Anna-Karin Berg; Gun Frisk; Torsten Tuvemo; Arne Andersson; Merja Roivainen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; enterovirus; type 1 diabetes; β-cells; human pancreatic islets; picornavirus; chemokines; nitric oxide; Pediatrik; Paediatric medicine; Pediatrisk medicin;

    Sammanfattning : The process of β-cell destruction that leads to type 1 diabetes (T1D) is incompletely understood and it is believed to be a result of both genetic and environmental factors. Enterovirus (EV) infections of the β-cells have been proposed to be involved, however, the effects of EV infections on human β-cells have been little investigated. LÄS MER

  3. 2. Reverse genetic studies of Enterovirus replication

    Författare :Anna Sävneby; A. Michael Lindberg; Björn Andersson; Peter Gierow; Jonas Waldenström; Martin Ryan; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Enterovirus; picornavirus; coxsackievirus; echovirus; rhinovirus; reverse genetics; replication; translation; transfection; cassette vector.; Virology; Virologi;

    Sammanfattning : Enteroviruses belong to the Picornaviridae family and are small icosahedral viruses with RNA genomes of positive polarity, containing a single open reading frame. They mostly cause mild or asymptomatic infections, but also a wide array of diseases including: poliomyelitis, encephalitis, gastroenteritis, aseptic meningitis, myocarditis, hand-foot-and-mouth disease, hepatitis and respiratory diseases, ranging from severe infections to the common cold. LÄS MER

  4. 3. Tissue tropism and oncolytic potential of enteroviruses

    Författare :Stina Israelsson; Michael Lindberg; Kjell Edman; Peter Gierow; Einar Everitt; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; picornavirus; enterovirus; echovirus; receptor; tropism; viral oncolysis; quantification; receptor interactions; colon cancer; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : .... LÄS MER

  5. 4. Enterovirus Implications in Type 1 Diabetes

    Författare :Monika Hodik; Hober didier; Uppsala universitet; []
    Nyckelord :Enterovirus; Coxsackie B virus; Type 1 diabetes; Pancreatitis;

    Sammanfattning : Human enteroviruses (HEVs), particularly Coxsackie B viruses (CVBs), might trigger the onset of type 1 diabetes (T1D), either by direct infection of the insulin-producing beta-cells or by an indirect inflammatory response. The overall aim of this thesis was to study the tropism of HEVs in isolated human pancreatic cell clusters in vitro including virus effects on islet function, gene-expression and ultrastructure. LÄS MER

  7. 5. Inflammatory Mediators and Enterovirus Infections in Human Islets of Langerhans

    Författare :Annika Moëll; Gun Frisk; Olle Korsgren; Bo Nilsson; Outi Vaarala; Uppsala universitet; []
    Nyckelord :Immunology; diabetes; islets of Langerhans; enterovirus; inflammatory mediators; cytokines; nicotinamide; Immunologi;

    Sammanfattning : Type 1 diabetes (T1D) is due to a selective loss of the insulin producing β-cells. However, the process responsible for this loss is still unknown. There is accumulating evidence that enteroviruses (EVs) are involved in T1D. In addition to direct virus-induced cytolysis, EVs could facilitate β-cell destruction by inducing inflammatory cytokines. LÄS MER