Sökning: "dna probe"

Visar resultat 36 - 40 av 121 avhandlingar innehållade orden dna probe.

  1. 36. Gene expression profiling with real-time PCR

    Författare :Anders Ståhlberg; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; single cell biology; reverse transcription; LightUp probe; cancer diagnostics; real-time PCR; gene expression profiling; tumor biology;

    Sammanfattning : The sequence of the entire human genome is available today, and this information can be used to understand, characterize, and treat complex diseases such as cancer. Many cellular functions related to survival, growth and differentiation are reflected in the gene expression pattern, and the ability to quantify transcription levels of specific genes is, and always has been, central to research on gene function. LÄS MER

  3. 37. Affinity biosensors based on a capacitive transducer

    Författare :Christine Berggren; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; self-assembled monolayers; capacitance; heavy metal ion; non-labeled; nucleic acid; DNA biosensor; Biosensor; immunosensor; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Capacitive biosensors were developed for several analytes such as hormones, interleukines, viruses and heavy metal ions. The sensing surfaces were prepared by immobilizing the biorecognition element to self-assembled monolayers (SAMs) on gold. SAMs form spontaneously on gold by adsorption of thiols, sulfides or disulfides. LÄS MER

  4. 38. Molecular Electronics : Insight from Ab-Initio Transport Simulations

    Författare :Jariyanee Prasongkit; Rajeev Ahuja; Magnus Paulsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular Electronics; Ab Initio; DNA Sequencing; Nanoscience; Graphene; Physics with spec. in Atomic; Molecular and Condensed Matter Physics; Fysik med inriktning mot atom- molekyl- och kondenserande materiens fysik;

    Sammanfattning : This thesis presents the theoretical studies of electronic transport in molecular electronic devices. Such devices have been proposed and investigated as a promising new approach that complements conventional silicon-based electronics. LÄS MER

  5. 39. Molecular Tools for Biomarker Detection

    Författare :Lei Chen; Ulf Landegren; Niko Hildebrandt; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Rolling circle amplification; padlock probe;

    Sammanfattning : The advance of biological research promotes the emerging of new methods and solutions to answer the biological questions. This thesis describes several new molecular tools and their applications for the detection of genomic and proteomic information with extremely high sensitivity and specificity or simplify such detection procedures without compromising the performance. LÄS MER

  7. 40. Extracting Genomic Variations using Selector Technology

    Författare :Magnus Isaksson; Mats Nilsson; Radoje Drmanac; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Selector; Selector probe; Genetic variation; Resequencing; Targeted sequencing; copy-number variations; MLGA; Bioinformatics; Next generation sequencing; NGS; Amplified single molecule; ASM; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Genetics; Genetik; Molekylär medicin; Molecular Medicine;

    Sammanfattning : This thesis describes the development and use of a new class of molecular tools called Selector probes, and its potential for investigations of genetic variation. The Selector technology provides multiplex amplification of targeted DNA sequences with a high specificity, and an enrichment factor in the same order of magnitude as PCR. LÄS MER