Sökning: "Selector probe"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Selector probe.
1. Extracting Genomic Variations using Selector Technology
Sammanfattning : This thesis describes the development and use of a new class of molecular tools called Selector probes, and its potential for investigations of genetic variation. The Selector technology provides multiplex amplification of targeted DNA sequences with a high specificity, and an enrichment factor in the same order of magnitude as PCR. LÄS MER
2. Readout Strategies for Biomolecular Analyses
Sammanfattning : This thesis describes three readout formats for molecular analyses. A common feature in all works is probing techniques that upon specific target recognition ideally results in equimolar amounts of DNA circles. These are then specifically amplified and detected using any of the techniques presented herein. LÄS MER
3. Single Molecule Detection : Microfluidic Automation and Digital Quantification
Sammanfattning : Much of recent progress in medical research and diagnostics has been enabled through the advances in molecular analysis technologies, which now permit the detection and analysis of single molecules with high sensitivity and specificity. Assay sensitivity is fundamentally limited by the efficiency of the detection method used for read-out. LÄS MER
4. Microfluidic and Molecular Tools for Genetic Analyses
Sammanfattning : Methods that enable interrogation of multiple genomic regions in parallel are very useful for efficient detection of genetic variation. Two different types of probes are described in this thesis that can be used for direct analysis or for sample preparation upstream of Next Generation Sequencing. LÄS MER
5. Development of new tools for multiplex genetic analyses
Sammanfattning : Several methods allowing the simultaneous interrogation of multiple qualities of nucleic acid samples have been developed recently. Although diverse in nature, many of these methods have common limitations. LÄS MER