Sökning: "dioxin receptor"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden dioxin receptor.

1. 1. Bioassay analysis of dioxin-like compounds : response interactions and environmental transformation of Ah receptor agonists

   Författare :Helena Olsman; Magnus Engwall; John P. Giesy; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioassay; dioxin-like; Ah receptor; Biology; Biologi; Biology; Biologi;

   Sammanfattning : Dioxin-like compounds mediate their toxicity by binding to the aryl hydrocarbon receptor (AhR) and through this receptor a cascade of biochemical and toxic events are triggered. Mechanism-specific dioxin bioassays utilise the AhR coupled induction of endogenous CYP1A proteins or reporter gene systems for detection of dioxin-like compounds and other AhR ligands. LÄS MER

3. 2. Mechanisms of regulation of dioxin receptor function

   Författare :Maria Lindebro; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The dioxin receptor is a ligand-inducible transcription factor that belongs to the basic helix-loop- helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors. The dioxin receptor is regulated in a spatial manner, where the unliganded dioxin receptor resides in the cell cytoplasm in a complex with heat shock protein 90 (hsp90). LÄS MER

4. 3. Computational methods for analyzing dioxin-like compounds and identifying potential aryl hydrocarbon receptor ligands : multivariate studies based on human and rodent in vitro data

   Författare :Malin Larsson; Patrik Andersson; Anna Linusson; Mats Tysklind; Scott Boyer; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dioxin-like compounds; multivariate analysis; toxic equivalency factor; quantitative structure-activity relationship; descriptors; virtual screening; in vitro; species variation; aryl hydrocarbon receptor;

   Sammanfattning : Polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) are omnipresent and persistent environmental pollutants. In particular, 29 congeners are of special concern, and these are usually referred to as dioxin-like compounds (DLCs). LÄS MER

5. 4. Genetic, environmental and life-style effects on androgen receptor function

   Författare :Christel Björk; Malmö Molekylärgenetisk reproduktionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproductive function; smoking; 4 .4-DDE; persistent organic pollutants; prostate cancer; Androgen receptor; prostate specific antigen; CAG polymorphism; TCDD; aryl hydrocarbon receptor; CB-153;

   Sammanfattning : Androgens regulate male reproductive function and their effects are mediated through the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat, encoding a stretch of glutamines, affecting the transcriptional activity of the AR. LÄS MER

7. 5. Sources of dioxins and other POPs to the marine environment : Identification and apportionment using pattern analysis and receptor modeling

   Författare :Kristina Sundqvist; Karin Wiberg; Mats Tysklind; Paul Geladi; Miriam Diamond; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; air-water gas exchange; chiral; congener pattern; enantiomer; enantiomeric fraction; fugacity; HCH; hexachlorocyclohexane; homologue profile; indicator congener; isomer pattern; pattern analysis; PCA; PCB; PCDD F; PMF; polychlorinated dibenzofuran; polychlorinated dibenzo-p-dioxin; polychlorinated biphenyl; positive matrix factorization; principal component analysis; receptor modeling; source apportioning; source; source tracing; Environmental chemistry; Miljökemi; Persistent organic compounds; Persistenta organiska föreningar;

   Sammanfattning : In the studies underlying this thesis, various source tracing techniques were applied to environmental samples from the Baltic region. Comprehensive sampling and analysis of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in surface sediments in Swedish coastal and offshore areas resulted in a unique data set for this region. LÄS MER