Sökning: "Scott Boyer"

Hittade 2 avhandlingar innehållade orden Scott Boyer.

1. 1. Towards new computational tools for predicting toxicity

   Författare :Swapnil Chavan; Ian Nicholls; Scott Boyer; Linnéuniversitetet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Acute toxicity; chronic toxicity; hERG; k-NN; LD50; LOEL; Munro database; QSAR; read-across; toxicity; Medicinsk kemi; Medical Chemistry;

   Sammanfattning : The toxicological screening of the numerous chemicals that we are exposed to requires significant cost and the use of animals. Accordingly, more efficient methods for the evaluation of toxicity are required to reduce cost and the number of animals used. LÄS MER

3. 2. Computational methods for analyzing dioxin-like compounds and identifying potential aryl hydrocarbon receptor ligands : multivariate studies based on human and rodent in vitro data

   Författare :Malin Larsson; Patrik Andersson; Anna Linusson; Mats Tysklind; Scott Boyer; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dioxin-like compounds; multivariate analysis; toxic equivalency factor; quantitative structure-activity relationship; descriptors; virtual screening; in vitro; species variation; aryl hydrocarbon receptor;

   Sammanfattning : Polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) are omnipresent and persistent environmental pollutants. In particular, 29 congeners are of special concern, and these are usually referred to as dioxin-like compounds (DLCs). LÄS MER