Sökning: "dimerization"
Visar resultat 1 - 5 av 91 avhandlingar innehållade ordet dimerization.
1. Lipoprotein lipase-unstable on purpose?
Sammanfattning : Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. It is a non-covalent, homodimeric and N-glycosylated protein, which is regulated in a tissue-specific manner and is dependent on an activator protein, apolipoprotein CII. Dissociation of active LPL dimers to monomers leads to loss of activity. LÄS MER
2. The effect of sequence truncation and amino-acid substitutions on the biophysical properties of protein S and calbindin D9k
Sammanfattning : Protein S is a modular protein and a cofactor in the protein C anticoagulant system. It consists of a Gla-module, a thrombin-sensitive loop, four EGF-modules and a SHBG-like module. LÄS MER
3. Properties of Protein and Polymer Systems
Sammanfattning : Interactions of proteins with other proteins, with polymers and with surfaces are of great practical importance within for instance protein purification, drug delivery, and food technology. The aim of this work is to increase the understanding of protein-protein, protein-polyelectrolyte, and protein-surface interactions, particularly concerning the role of electrostatic interactions in these systems. LÄS MER
4. Structure and morphology control of organic semiconductors for functional optoelectronic applications
Sammanfattning : The functionality and application of organic semiconductors are largely dependent on their constituent structure and morphology. This thesis presents a number of functional and novel approaches for the control and tuning of structural and morphological features of a variety of organic semiconductor materials, and also demonstrates that these approaches can be utilized for improved device operation of field-effect transistors, organic solar cells and light-emitting electrochemical cells. LÄS MER
5. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties
Sammanfattning : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. LÄS MER