Sökning: "Functionally Selective Ligand"

Hittade 3 avhandlingar innehållade orden Functionally Selective Ligand.

1. 1. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties

   Författare :Mariama Jaiteh; Jens Carlsson; David E Gloriam; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Docking; Virtual Screening; Homology Modeling; Molecular Dynamics Simulation; Chemical Library; Functionally Selective Ligand; Polypharmacology; Dimerization; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Sammanfattning : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. LÄS MER

3. 2. Ion channels in drug discovery : focus on biological assays

   Författare :Kim Dekermendjian; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ion channels; GABAA receptor; sodium channels; TRPM8; drug discovery; high throughput screening assays; FLIPR; automated electrophysiology;

   Sammanfattning : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. LÄS MER

4. 3. Studies of presenilin function in neurodegeneration and in human embryonic CNS during development

   Författare :Beata Kostyszyn; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity for cleaving transmembrane proteins such as the amyloid precursor protein (APP), Notch receptors and ligands. LÄS MER