Sökning: "Nonsense-mediated decay"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Nonsense-mediated decay.
1. Simplified Nonsense: New Methods for Interrogating NMD
Sammanfattning : Nonsense mediated decay (NMD) is a pathway that regulates RNA turnover. Since its discovery, this pathway has been implicated in a variety of cellular processes ranging from differentiation to the restriction of viral replication. LÄS MER
2. Molecular Mechanisms of Frontotemporal Lobar Degeneration
Sammanfattning : The aim of this thesis was to identify genetic factors involved in frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder clinically characterised by a progressive change in personality, behaviour and language. FTLD is a genetically complex disorder and a positive family history is found in up to 40% of the cases. LÄS MER
3. The regulation of incorrect splicing of ISCU in hereditary myopathy with lactic acidosis
Sammanfattning : Patients suffering from hereditary myopathy with lactic acidosis (HML) can be found in the northern Swedish counties of Ångermanland and Västerbotten. HML is a rare autosomal recessive disease where patients display a low tolerance to exercise at an early age. LÄS MER
4. Regulation of pre-mRNA splicing and mRNA degradation in Saccharomyces cerevisiae
Sammanfattning : Messenger RNAs are transcribed and co-transcriptionally processed in the nucleus, and transported to the cytoplasm. In the cytoplasm, mRNAs serve as the template for protein synthesis and are eventually degraded. The removal of intron sequences from a precursor mRNA is termed splicing and is carried out by the dynamic spliceosome. LÄS MER
5. Biogenesis of messenger and ribosomal RNPs in the eukaryotic cell
Sammanfattning : In eukaryotic cells, gene expression involves multi-step processes in the nucleus and the cytoplasm. The different processes engage specific RNA-protein complexes, RNPs. Upon activation of most, if not all genes, a precursor RNA molecule is synthesized that has to be extensively processed and modified. LÄS MER