Sökning: "Progranulin"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Progranulin.

  1. 1. The impact of the progranulin-sortilin axis on breast cancer stem cell activity and patient outcome

    Författare :Karoline Berger; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; biomarker; cancer stem cells; microenvironment; progranulin; sortilin; interleukin-6; targeted therapy; prognostic;

    Sammanfattning : Breast cancer is the most common cancer in women worldwide. Still today, despite current breast cancer therapies, many patients experience treatment resistance and relapse, which are believed to be due to failure in targeting treatment-resistant cancer stem cells. LÄS MER

  3. 2. Molecular Mechanisms of Frontotemporal Lobar Degeneration

    Författare :Lena Skoglund; Anna Glaser; Martin Ingelsson; Lars Lannfelt; Stuart Pickering-Brown; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Frontotemporal lobar degeneration; Frontotemporal dementia; Tau; Progranulin; Alternative splicing; Nonsense-mediated decay; Haploinsufficiency;

    Sammanfattning : The aim of this thesis was to identify genetic factors involved in frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder clinically characterised by a progressive change in personality, behaviour and language. FTLD is a genetically complex disorder and a positive family history is found in up to 40% of the cases. LÄS MER

  4. 3. Bridging the gap between lipid dyshomeostasis and brain disorders : role of prosaposin and progranulin

    Författare :Yachao He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Brain tissue is the second-highest lipid-containing tissue after adipose in the human body. Lipid homeostasis maintenance requires the coordination of multiple cellular organelles. Pathogenesis of brain disorders, especially Parkinson’s disease (PD), usually involves different dysfunctional pathways that intimately link to lipid homeostasis. LÄS MER

  5. 4. The breast cancer microenvironment and cancer cell secretion - specific effects on cancer progression and subtypes of cancer cells

    Författare :Emma Persson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; cancer microenvironment; secretion; hypoxia;

    Sammanfattning : Breast cancer is the cancer form responsible for the most cancer-related deaths among women worldwide, and novel targeted therapies are highly needed. The tumor microenvironment consists of several components, including different cell types, extracellular matrix, oxygen and nutrient gradients and soluble factors that plays a key role in cancer progression. LÄS MER

  7. 5. Genetic characterization of patients with frontotemporal dementia and amyotrophic lateral sclerosis in the Nordic countries

    Författare :Huei-Hsin Chiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Frontotemporal dementia (FTD) is the second most common form of neurodegenerative disease affecting people under the age of 65 years. The general symptoms are dysfunctions in behavior and/or language. LÄS MER