Sökning: "de novo gene evolution"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden de novo gene evolution.

  1. 1. The evolution of ribonucleotide reductases

    Författare :Daniel Lundin; Anthony Poole; Britt-Marie Sjöberg; Christos Ouzounis; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolution; ribonucleotide reductase; horizontal gene transfer; phylogeny; protein classification; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Ribonucleotide reductase (RNR) catalyses the transformation of RNA building blocks, ribonucleotides, to DNA building blocks, deoxyribonucleotides. This is the only extant reaction pathway for de novo synthesis of DNA building blocks and the enzyme is thus necessary for life. RNR is found in all but a few organisms. LÄS MER

  3. 2. Mechanisms of Antibiotic Resistance Evolution

    Författare :Michael Knopp; Dan Andersson; Anca Segall; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance evolution; Escherichia coli; Salmonella; porins; fitness; epistasis; strain-specificity; sub-MIC; de novo gene evolution;

    Sammanfattning : The continuing emergence and spread of antibiotic resistant bacteria are a threat to various applications in modern medicine and impose a strong economic burden on health systems. The development of new antibiotics is slow and cannot counterbalance the dissemination of resistant bacteria. LÄS MER

  4. 3. Genomic studies of mating system variation in flowering plants

    Författare :Juanita Gutiérrez-Valencia; Tanja Slotte; Magne Friberg; Mario Vallejo-Marín; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mating system evolution; cross- and self-fertilization; distyly; supergenes; complex phenotypic polymorphism; convergent evolution; homostyly; loss-of-function mutation; intrasexual competition; pollen; purifying selection; Linum; Arabis alpina; Ecology and Evolution; ekologi och evolution;

    Sammanfattning : The striking diversity of reproductive strategies that flowering plants exhibit remains one of the most intriguing conundrums in evolutionary biology. Pollination-related traits and mating system strategies have a major impact on the processes shaping plant evolution through their effects on genetic diversity and selection. LÄS MER

  5. 4. Deoxyribonucleoside kinases in bacteria, plants and humans

    Författare :Anders Ranegaard Clausen; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; anti-viral drugs; gene therapy; cancer; evolution; nucleoside analog; deoxyribonucleoside kinase; thymidine kinase;

    Sammanfattning : Deoxyribonucleoside triphosphates (dNTPs) are the building blocks of DNA and can be synthesized either de novo or via salvage pathways. The first reaction in the salvage pathway of dNTPs is the conversion of deoxyribonucleosides (dN) into the deoxyribonucleoside monophosphate (dNMP). LÄS MER

  7. 5. Hopeful monsters: The role of hybrids in adaptation : The impact of hybridisation and genetic diversity on adaptation to stressful and novel environments

    Författare :Ciaran Gilchrist; Rike Stelkens; Christopher Wheat; Linda Laikre; Mathilde Cordellier; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Experimental evolution; Saccharomyces cerevisiae; population genetics; hybridisation; adaptation; aneuploidy; comparative genomics; evolve-and-resequence; de novo mutations; evolutionary parallelism; populationsgenetik; Population Genetics;

    Sammanfattning : Adaptation to novel environments can only occur if natural selection has the raw material to act upon. But small, endangered populations are often genetically depleted, and the acquisition of beneficial de novo mutations often takes too long when population face quick and extreme environmental change. LÄS MER