Sökning: "nucleoside analog"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden nucleoside analog.

  1. 1. Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA

    Författare :Mia Bjerke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nucleoside analogs are modified nucleosides used in treatment of cancer and viral infections. They are dependent on intracellular phosphorylation to be pharmacologically active. Deoxyribonucleoside kinases catalyze the rate-limiting step in the phosphorylation of many clinically used nucleoside analogs. LÄS MER

  3. 2. Deoxyribonucleoside kinases in bacteria, plants and humans

    Författare :Anders Ranegaard Clausen; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; anti-viral drugs; gene therapy; cancer; evolution; nucleoside analog; deoxyribonucleoside kinase; thymidine kinase;

    Sammanfattning : Deoxyribonucleoside triphosphates (dNTPs) are the building blocks of DNA and can be synthesized either de novo or via salvage pathways. The first reaction in the salvage pathway of dNTPs is the conversion of deoxyribonucleosides (dN) into the deoxyribonucleoside monophosphate (dNMP). LÄS MER

  4. 3. Investigation of antiviral and anticancer nucleoside analog substrate recognition of drosophila melanogaster and herpes virus deoxyribonucleoside kinases

    Författare :Nicola Solaroli; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The deoxyribonucleoside kinase of the fruit fly Drosophila melanogaster (Dm-dNK) is a multisubstrate enzyme that phosphorylates pyrimidine and purine deoxyribonucleosides as well as several anticancer and antiviral nucleoside analogs. Dm-dNK is sequence related to the human deoxycytidine kinase (dCK), deoxyguanosine kinase (dGK) and thymidine kinase 2 (M), as well as to the herpes simplex virus type-1 thymidine kinase (Hsv-1 TK). LÄS MER

  5. 4. Identification and characterization of nucleoside and nucleotide kinases : pharmacological activation of anti-cancer and anti-viral nucleoside analogs

    Författare :An R Van Rompay; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cells require deoxyribonucleotides to synthesize DNA. Structurally modified precursors of deoxyribonucleotides, i.e. nucleoside analogs, are used as anti-viral and anti-cancer compounds. LÄS MER

  7. 5. Nucleoside analog phosphorylation and mitochondrial enzymes : studies on molecular targets of the anti-leukemic compound 9-beta-D-arabinofuranosylguanine

    Författare :Sophie Curbo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nucleoside analogs are commonly used in treatment of cancer and viral infections. A way to improve the therapies would be to minimize the acquirement of resistance and side effects such as delayed cytotoxicity. LÄS MER