Sökning: "cytostatic"

Visar resultat 1 - 5 av 65 avhandlingar innehållade ordet cytostatic.

  1. 1. Modern Computational Physical Chemistry : An Introduction to Biomolecular Radiation Damage and Phototoxicity

    Författare :Jorge Llano; Leif A. Eriksson; Ulf Ryde; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; statistical mechanics; biophysical chemistry; interface; surface thermodynamics; bioelectrochemistry; ionizing radiation; radiation therapy; condensed matter; computational chemistry; nucleic acids; radiation damage; electrode potential; electronic transport; photochemistry; strand break; photodynamic action; cytostatic; solvation; solvated electron; absolute potential; chemical potential; Biologi; Biology; Biologi;

    Sammanfattning : The realm of molecular physical chemistry ranges from the structure of matter and the fundamental atomic and molecular interactions to the macroscopic properties and processes arising from the average microscopic behaviour.Herein, the conventional electrodic problem is recast into the simpler molecular problem of finding the electrochemical, real chemical, and chemical potentials of the species involved in redox half-reactions. LÄS MER

  3. 2. Malignant glioma : experimental studies with an estrogen-linked cytostatic

    Författare :Eva von Schoultz; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; malignant glioma; meningioma; glioma cells; sex steroids; estramustine; nor-nitrogen mustard; estramustine- binding protein; DNA damage; cell membrane;

    Sammanfattning : Malignant gliomas are the most common primary brain tumors in adults. Patients with these highly malignant tumors have an extremely poor prognosis. The situation with a highly proliferative tumor in a non-proliferating tissue should favor cytostatic treatment but so far the role of conventional chemotherapy has been adjunctive. LÄS MER

  4. 3. Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin : Activation and Binding to DNA

    Författare :Johan Raber; David van der Spoel; Paolo Carloni; Uppsala universitet; []
    Nyckelord :Quantum chemistry; cisplatin; quantum chemistry; DNA; density functional theory; activation; JM118; substitution reaction; Platinum; guanine; adenine; cytostatic drug; aquation; anation; activation; Kvantkemi;

    Sammanfattning : The serendipitous discovery of the potent cytotoxic properties of cisplatin brought about a revolution in the treatment of certain types of cancer, but almost fifty years later, there still remain unknown areas in the chemistry of cisplatin. There are questions regarding which form of the drug reaches its DNA target, or why certain DNA sequences are more preferred than others for reaction with cisplatin. LÄS MER

  5. 4. Significance of glutathione transferases in the resistance of tumor cells to alkylating cytostatic drugs

    Författare :Víctor M. Castro; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  7. 5. In vitro studies of cytostatic drugs and growth factors on leukemic and normal hematopoietic cells : based on in vivo intracellular pharmacokinetics

    Författare :Britt Sundman-Engberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ANLL; Normal bone marrow; in vitro; predictive tests; pharmacokinetics; cytostatic drugs; growthfactors;

    Sammanfattning : The aims were to develop, evaluate and apply in vitro methods for cytostatic drug sensitivity, based on intracellular concentrations found after in vivo infusions. The intracellular pharmacokinetics of anthraquinones and ara-C were compared during and after infusion to leukemic patients. Drug concentrations were evaluated with HPLC. LÄS MER