Sökning: "cynomolgus macaques"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden cynomolgus macaques.

  1. 1. Testosterone and the postmenopausal breast : aspects on cell proliferation and mammographic density

    Författare :Marie Hofling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Menopause; testosterone; breast cell proliferation; fine needle aspiration biopsy; mammographic density; Syndecan-1; androgen receptor; cynomolgus macaques;

    Sammanfattning : The breast is a target organ for sex steroids, and hormonal treatments have been associated with a risk of breast cancer. There is increasing interest in androgen treatment for postmenopausal women. Testosterone has been shown to improve bone density, body composition, mood, psychosexual function and general well-being. LÄS MER

  3. 2. Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation

    Författare :Erika Isaksson Friman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Oral contraceptives; hormone replacement therapy; breast epithelial proliferation; cynomolgus macaques; ER-alpha and ER-beta; PRA and PRB; tamoxifen; IGF-I; p53.;

    Sammanfattning : Breast cancer is the most common malignancy among women in the western world. Hormonal treatments for contraception and replacement after menopause have been associated with an increased risk of breast cancer. The basis of risk associated with hormonal therapies may lie in the regulation of cell proliferation. LÄS MER

  4. 3. Hormone therapy and the breast : aspects on proliferation, apoptosis and mammographic density

    Författare :Peter Conner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Breast cell proliferation; fine needle aspiration cytology; menopause; hormone replacement therapy; tibolone; mammographic breast density; continuous combined hormone therapy; p53; apoptosis; cynomolgus macaques.;

    Sammanfattning : Breast cancer is the major malignancy among women in the western world. The breast is clearly a target organ for sex steroid hormones and hormonal treatments have been associated with an increased risk of breast cancer. Still, basic knowledge as to how sex steroids influence the normal breast is remarkably poor. LÄS MER

  5. 4. Definition of immunoglobulin germline genes by next generation sequencing for studies of antigen-specific B cell responses

    Författare :Néstor Vázquez Bernat; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Immunoglobulins play a critical role in the adaptive immune system, existing as cell surface-expressed B cell receptors and secreted antibodies. Circulating antibodies are the main correlate of protective immunity for most vaccines. LÄS MER

  7. 5. Virus tropism and neutralization response in SIV infection

    Författare :Anna Laurén; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; Medicin människa och djur ; Medicine human and vertebrates ; HIV; SIV; mode of CCR5 use; CD4-independence; macrophage tropism; coreceptor use; neutralization; evolution; pathogenesis;

    Sammanfattning : Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. LÄS MER