Sökning: "CD4-independence"

Hittade 4 avhandlingar innehållade ordet CD4-independence.

  1. 1. Virus tropism and neutralization response in SIV infection

    Författare :Anna Laurén; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; Medicin människa och djur ; Medicine human and vertebrates ; HIV; SIV; mode of CCR5 use; CD4-independence; macrophage tropism; coreceptor use; neutralization; evolution; pathogenesis;

    Sammanfattning : Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. LÄS MER

  3. 2. Receptor use of primate lentiviruses

    Författare :Dalma Vödrös; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; SIV; animal models; receptor use; neutralizing antibodies; CD4-independence;

    Sammanfattning : Human and simian immunodeficiency viruses (HIV and SIV) enter target cells using CD4, the primary cell surface receptor and a secondary receptor, called coreceptor. Coreceptor use of HIV can be related to other biological features of the virus and to the severity of infection as well. LÄS MER

  4. 3. Studies on HIV-2 antibody mediated neutralisation, coreceptor usage and in vivo tropism

    Författare :Andreas Mörner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-2; neutralising antibodies; V3; combinatorial library; phage display; Fab fragment; coreceptor; CCR5; CXCR4; HIV encephalitis; macrophages microglia;

    Sammanfattning : Human immunodeficiency virus type 2 (HIV-2) is the second virus that causes AIDS in humans. It has a genetic identity with HIV-1 of 40-60% and similar genetic organisation and biological properties, but the two viruses are distinguished certain features. LÄS MER

  5. 4. Functional studies on the interaction of immunoglobulins with HIV-2 envelope

    Författare :Samer Sourial; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; Glycoprotein; Antibodies lgA IgG; V3; CD4; Neutralization; Immunization;

    Sammanfattning : Infection with HIV-2 has a much more limited geographic distribution than HIV-1, being less readily transmitted and is generally less pathogenic. The role of immunoglobulins in defence against pathogens in different body compartments is known, where IgG is the principal isotype in the blood and extracellular fluid while lgA predominates in the mucosal compartment. LÄS MER