Sökning: "coreceptor use"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden coreceptor use.

  1. 1. Evolution of HIV-1 coreceptor use in relation to pathogenesis

    Författare :Ingrid Karlsson; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; RANTES; higly active antiretroviral therapy; pathogenesis; lymphoid tissue; cehmokine receptor; biological phenotype; coreceptor; HIV-1; evolution;

    Sammanfattning : HIV-1 uses the coreceptors CCR5 and/or CXCR4 in addition to CD4 to enter the host cell. CCR5-using HIV-1 (R5 phenotype) appears to transmit infection and usually dominates the early stages of disease. LÄS MER

  3. 2. Virus tropism and neutralization response in SIV infection

    Författare :Anna Laurén; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; Medicin människa och djur ; Medicine human and vertebrates ; HIV; SIV; mode of CCR5 use; CD4-independence; macrophage tropism; coreceptor use; neutralization; evolution; pathogenesis;

    Sammanfattning : Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and CXCR4. LÄS MER

  4. 3. Receptor use of primate lentiviruses

    Författare :Dalma Vödrös; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; SIV; animal models; receptor use; neutralizing antibodies; CD4-independence;

    Sammanfattning : Human and simian immunodeficiency viruses (HIV and SIV) enter target cells using CD4, the primary cell surface receptor and a secondary receptor, called coreceptor. Coreceptor use of HIV can be related to other biological features of the virus and to the severity of infection as well. LÄS MER

  5. 4. Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage

    Författare :Liselotte Antonsson; Drug Target Discovery; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; evolution; pathogenesis; cerebrospinal fluid; Medicine human and vertebrates ; TAK-779; RANTES; CXCR4; CCR5; coreceptor; GPCR; HIV-1;

    Sammanfattning : The chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of infected individuals. LÄS MER

  7. 5. Amino acid predictors of HIV-1 coreceptor use in different subtypes and their application to antiretroviral treatment

    Författare :Lotta Pramanik Sollerkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) group M is responsible for the HIV pandemic and has great genetic variability. The main subtypes and circulating recombinant forms belonging to this group differ in their worldwide distribution, their disease progression patterns, as well as in their coreceptor use phenotype distributions. LÄS MER