Sökning: "ER-alpha and ER-beta"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden ER-alpha and ER-beta.

  1. 1. Polymorphism in sex steroid-related genes. Effects on hormone levels and behavior

    Författare :Lars Westberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sex steroids; androgen receptor; estrogen receptor; progesterone receptor; polymorphism; genetics; association study; prolactin; personality; premenstrual dysphoric disorder; Parkinson s disease;

    Sammanfattning : Genetic factors are important for variations between individuals with respect to most humantraits and diseases. Sex steroids are of profound importance for reproduction, metabolism,cardiovascular function and bone formation. They are potent regulators of their ownsynthesis as well as of that of other hormones, including prolactin. LÄS MER

  3. 2. Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation

    Författare :Erika Isaksson Friman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Oral contraceptives; hormone replacement therapy; breast epithelial proliferation; cynomolgus macaques; ER-alpha and ER-beta; PRA and PRB; tamoxifen; IGF-I; p53.;

    Sammanfattning : Breast cancer is the most common malignancy among women in the western world. Hormonal treatments for contraception and replacement after menopause have been associated with an increased risk of breast cancer. The basis of risk associated with hormonal therapies may lie in the regulation of cell proliferation. LÄS MER

  4. 3. Molecular mechanisms of estrogen and antiestrogen action

    Författare :Tomas Barkhem; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen receptor; SHBG; tamoxifen; raloxifene; pS2; p1 60 coactivator; SRC-1; TIF-2;

    Sammanfattning : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. LÄS MER

  5. 4. Signal transduction via estrogen receptors (ERs) and estrogen receptor-related receptors (ERRs)

    Författare :Katarina Pettersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogens influence post-natal development and function of the female reproductive system and other organs including bone and cardiovascular system. Estrogens are also involved in the development and growth of certain cancers in e.g. breast and uterine endometrium. LÄS MER

  7. 5. Modulation of estrogen receptors alpha and beta. Effects on the immune system

    Författare :Malin Erlandsson; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Estrogen affects the development and function of the immune system. Gonadectomized mice treated with estrogen display suppressed T and B lymphopoiesis and inhibited T cell and granulocyte dependent inflammation, while mature B cells are stimulated to produce more immunoglobulins. LÄS MER