Sökning: "co-stimulation"
Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet co-stimulation.
1. Co-stimulation in gut mucosal immunity. Evidence of a differential regulationof local and systemic responses
Sammanfattning : In recent years we have learned that co-stimulatory factors are required as second signals for optimal T cell stimulation. Most types of immune responses are, therefore, dependent on the co-stimulatory signals that are provided by infection or immunization. LÄS MER
2. Smoking and T cell co-stimulation in rheumatoid arthritis
Sammanfattning : In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. LÄS MER
3. Evaluating antitumoral lymphocytes for adoptive cell therapy : oxidative stress, neoantigen processing and co-stimulation
Sammanfattning : Rapid advancement in the field of immunotherapy has changed the treatment landscape of cancer, especially with the approval of immune checkpoint inhibitors for a wide range of cancer types. However, a large proportion of patients does not benefit from this treatment. LÄS MER
4. On the role of dendritic cells in HIV-1 infection
Sammanfattning : Dendritic cells (DCs) are antigen-presenting cells with the capacity to initiate primary T cell responses against pathogens such as HIV-1. In addition, DCs express the receptors required for HIV-1 infection and as DCs are prevalent in the mucosa, they encounter the virus early after sexual transmission. LÄS MER
5. Classical cadherins and the thyroid. Studies on organ development and epithelial differentiation
Sammanfattning : The cadherins are key regulators of tissue patterning and organ formation. E-cadherin is important for cell-cell adhesion and promotes epithelial morphogenesis and maintenance of the epithelial phenotype. LÄS MER