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Visar resultat 1 - 5 av 180 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Risk Factors for Stroke in Adult Men : A Population-based Study

    Författare :Bernice Wiberg; Lars Lind; Johan Sundström; Björn Zethelius; Peter Appelros; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; risk factor; stroke; TIA; lipoproteins; fatty acids; insulin resistance; proinsulin; clamp; cognitive function; epidemiology; Trail Making Test; stroke mortality; dependency; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi; Medicinsk vetenskap; Medical Science;

    Sammanfattning : In the last decades our knowledge concerning cardiovascular risk factors has grown rapidly through results from longitudinal studies. However, despite new treatment, in Western countries coronary heart disease remains the leading cause of death and stroke is still the leading cause of severe disability. LÄS MER

  3. 2. Insulin-antagonistic neurohormonal pathways in the development of insulin resistance and type 2 diabetes

    Författare :Martin Lundqvist; Jan W Eriksson; Niclas Abrahamsson; André van Beek; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucagon; cortisol; ACTH; growth hormone; counter-regulation; clamp; hypoglycemia; hyperglycemia; obesity; type 2 diabetes; inflammation;

    Sammanfattning : According to the current paradigm, the development of type 2 diabetes is driven by insulin resistance and the gradual failure of beta cells to compensate for this by secreting adequate amounts of insulin. Obesity is an important risk factor for type 2 diabetes and is considered to influence disease development primarily by induction of insulin resistance, via mechanisms that have not been fully elucidated. LÄS MER

  4. 3. Glucose metabolism in patients with exocrine pancreatic adenocarcinoma

    Författare :Johan Permert; Linköpings universitet; []
    Nyckelord :endocrine pancreatic function; euglycemic hyperinsulinemic clamp; exocrine pancreatic adenocarcinoma; glucose metabolism; glyccogen synthesis; hyperglycemic clamp; immunohistochemistry; insulin resistance; insulin secretion; in situ hybridization; islet amuyloid polypeptide IAPP ; radioimmunoassay; subtotal pancreatectomy; MEDICINE; MEDICIN;

    Sammanfattning : Carc.inoma of the exocrine pancreas is the fifth leading cause of cancer death in the Western world and the survival rate is one of the lowest for cancers of any site. Pancreatic cancer is characterized by pronounced, early cachexia and frequent metabolic complications. LÄS MER

  5. 4. Patch clamp and calcium studies on human colonic mucosal cells

    Författare :Peter Sand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human; colon crypt; HT29; K channel; Ca oscillations; volume regulation; patch clamp;

    Sammanfattning : Background: The main function of the large intestine is to fine-tune electrolyte and water balance. This is achieved through the consorted action of ion channels, transporters and pumps. Failures of this system can lead to diarrhoea. LÄS MER

  7. 5. Methods for elucidating membrane protein structure and function

    Författare :Carolina Trkulja; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; patch clamp; antibodies; mass spectrometry; ion channels; proteomics; fluorescence; TRPV1; cholesterol.; limited proteolysis; Membrane proteins;

    Sammanfattning : Elucidation of the structure-function relationship of membrane proteins increases our understanding of many biological processes, both physiological and pathological. However, membrane proteins have been notoriously difficult to study, having part of their structure embedded into the lipid cell membrane. LÄS MER