Sökning: "colon crypt"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden colon crypt.

  1. 1. Experimental Studies of Ursolic Acid and Alkaline Sphingomyelinase in Colon Cancer and Colitis

    Författare :David Andersson; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Sphingomyelin (SM) is a sphingolipid present in all eukaryotic cell membranes. Hydrolysis of SM by sphingomyelinase (SMase) generates ceramide, which has effects on cell-cycle regulation and apoptosis. LÄS MER

  2. 2. Colon cancer specific cytochrome P450 2W1 : polymorphism, membrane topology and endogenous roles in development

    Författare :Jia Guo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Cytochrome P450 2W1 (CYP2W1) belongs to a family of drug metabolizing monooxygenases with an unidentified yet endogenous function. CYP2W1 expression pattern has characteristic features of oncofetal genes. Previous studies have shown significant levels of CYP2W1 protein in 30% of human colon cancers and in 50% of corresponding liver metastases. LÄS MER

  3. 3. Patch clamp and calcium studies on human colonic mucosal cells

    Författare :Peter Sand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Human; colon crypt; HT29; K channel; Ca oscillations; volume regulation; patch clamp;

    Sammanfattning : Background: The main function of the large intestine is to fine-tune electrolyte and water balance. This is achieved through the consorted action of ion channels, transporters and pumps. Failures of this system can lead to diarrhoea. LÄS MER

  4. 4. Specific and nonspecific immune mechanisms in human gut : a comparative study of normal and ulcerative colitis intestine

    Författare :Moorix Mo-Wai Yeung; Sten Hammarström; Marie-Louise Hammarström; Marita Troye-Blomberg; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestine; ulcerative colitis; lymphoid aggregates; intraepithelial lymphocytes; lamina propria lymphocytes; γδT-cells; cytokines; IL-2; carcinoembryonic antigen; biliary glycoprotein; epithelial cells; glycocalyx;

    Sammanfattning : The intestine, with its large mucosal surface area, digests and absorbs food nutrients and maintains a beneficial microbial flora in the colon. Local protective immune responses against intestinal pathogens ensure the survival of the individual. These immune reactions are both specific and non-specific in nature. LÄS MER

  5. 5. Paracellular permeability of intestinal epithelia.An in vivo study

    Författare :Britt-Marie Fihn; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :paracellular permeability; intestinal epithelia; deoxycholic acid; cholera toxin; glucose absorption; water transport;

    Sammanfattning : Aim: Investigate the importance of paracellular transport of water and solutes during physiological and pathophysiological conditions. Methods: The transport of small water-soluble inert permeability markers, was studied in jejunum and colon in anesthetized rats and cats during normal conditions and during exposure to cholera toxin (CT) and deoxycholic acid (DCA). LÄS MER