Sökning: "chk2"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet chk2.

  1. 1. Regulation of DNA damage responses by the Myc oncogene : implications for future anti-cancer therapies

    Författare :Andreas Höglund; Jonas Nilsson; Thomas Helleday; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Myc; DNA damage; Decitabine; Chk1; Chk2; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated expression of Myc carry a selective advantage against its neighbours due to the fact that Myc-mediated transcription governs crucial cellular events such as proliferation and growth. LÄS MER

  3. 2. The role of RNA-binding motif 3 in epithelial ovarian cancer: A biomarker discovery approach

    Författare :Åsa Ehlén; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA integrity checkpoint; cisplatin treatment; prognostic predictive marker; RBM3; epithelial ovarian cancer; Chk1; Chk2; MCM3;

    Sammanfattning : Epithelial ovarian cancer (EOC) is the most lethal of all gynaecological malignancies and there is an urgent need to develop new prognostic and treatment predictive biomarkers for a more efficient therapy. The discovery of the RNA-binding motif protein 3 (RBM3) as a putative cancer biomarker was based on its differential expression in various cancer forms in the Human Protein Atlas (HPA). LÄS MER

  4. 3. In vitro radiobiological effects of 131I on thyroid cells: towards a mechanistic understanding of thyroid stunning

    Författare :Nirmal Bhogal; Göteborgs universitet; []
    Nyckelord :thyroid; radioiodide; stunning; 131I; stress response; DNA damage; Chk2; H2AX; micronuclei; cell cycle;

    Sammanfattning : .... LÄS MER

  5. 4. Radiobiological effects of alpha-particles from Astatine-211: From DNA damage to cell death

    Författare :Kristina Claesson; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : ABSTRACT In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an -particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. LÄS MER

  7. 5. DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning

    Författare :Madeleine Nordén; Göteborgs universitet; []
    Nyckelord :thyroid; radioiodide; thyroid stunning; NIS; cell cycle; genotoxic stress; DNA damage; H2AX; ATM;

    Sammanfattning : 131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. LÄS MER