Sökning: "cisplatin treatment"

Visar resultat 1 - 5 av 73 avhandlingar innehållade orden cisplatin treatment.

  1. 1. ASNA1 and cisplatin resistance studies in C. elegans and in human tumor cells

    Detta är en avhandling från Umeå : Umeå Universitet

    Författare :Oskar Hemmingsson; Umeå universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ASNA1; Cisplatin; C. elegans; Drug resistance; Apoptosis; MEDICINE Surgery; MEDICIN Kirurgi; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; kirurgi; Surgery; onkologi; Oncology; cellforskning; cellforskning;

    Sammanfattning : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. LÄS MER

  2. 2. Bacterial toxins for cancer treatment

    Detta är en avhandling från Umeå : Medicinsk biovetenskap

    Författare :David Johansson; Umeå universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha‐toxin; AC‐toxin; mesothelioma; lung cancer; glioma; breast cancer; caspases; MAP-Kinase; verotoxin‐1; cisplatin; apoptosis; Gb3; drug resistance; MEDICINE Chemistry Clinical chemistry; MEDICIN Kemi Klinisk kemi;

    Sammanfattning : Even though anti‐cancer chemotherapy has been continuously improved during the last decades. problems with adverse effects and drug resistance still constitutes a considerable obstacle and sets a demand for new effective treatment options. LÄS MER

  3. 3. Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin Activation and Binding to DNA

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johan Raber; Uppsala universitet.; [2007]
    Nyckelord :Quantum chemistry; cisplatin; quantum chemistry; DNA; density functional theory; activation; JM118; substitution reaction; Platinum; guanine; adenine; cytostatic drug; aquation; anation; activation; Kvantkemi;

    Sammanfattning : The serendipitous discovery of the potent cytotoxic properties of cisplatin brought about a revolution in the treatment of certain types of cancer, but almost fifty years later, there still remain unknown areas in the chemistry of cisplatin. There are questions regarding which form of the drug reaches its DNA target, or why certain DNA sequences are more preferred than others for reaction with cisplatin. LÄS MER

  4. 4. Electropermeabilization in Experimental Tumour Treatment: Dosimetry and Tissue Effects

    Detta är en avhandling från Department of Radiation Physics, Lund university

    Författare :Per Engström; Lunds universitet.; Lund University.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; liver; electroporation; ischemia; Electropermeabilization; ECT; Tumor; 111-In-BLMC; 99m-Tc-DTPA; glioma; rat; electric pulses; Impedance spectrometry; treatment; Physics; Fysik;

    Sammanfattning : Short, electric high-voltage pulses can be used to transiently increase the permeability of cell membranes without significant loss of cell viability. During this period of time, extracellular and normally non-permeant, molecules are accessed the cytoplasm and the cell nucleus. LÄS MER

  5. 5. Studies of radioactive cisplatin (191Pt) for tumour imaging and therapy

    Detta är en avhandling från Radiaiton Physics, Malmö University Hospital, SE-205 02 Malmö, Sweden

    Författare :Johan Areberg; Lunds universitet.; Lund University.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; mice; in vitro; gamma camera; tumour imaging; platinum pharmacokinetics; cisplatin; radioactive; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : A radioactive variant of the cytostatic agent cis-dichlorodiammineplatinum(II), cisplatin, was synthesised from 191PtCl4. The 191Pt-cisplatin was found to be a sterile product of high radionuclide, radiochemical and chemical purity. LÄS MER