Sökning: "DNA integrity checkpoint"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden DNA integrity checkpoint.

1. 1. Replication Dynamics in the DNA Damage Response

   Författare :Petra Groth; Thomas Helleday; Geroge Iliakis; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA replication; homologous recombination; DNA double strand-breaks; ionizing radiation; alkylating agents; NATURAL SCIENCES; NATURVETENSKAP; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

   Sammanfattning : Faithful DNA replication is essential and the induction of replication stress may have profound effects on genomic integrity. This is demonstrated by the formation of DNA double strand breaks (DSBs), considered to be the most toxic DNA lesions, at stalled replication forks. LÄS MER

3. 2. DNA precursor asymmetries, Mismatch Repair and their effect on mutation specificity

   Författare :Robert Buckland; Andrei Chabes; Juan Méndez; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Replication Fidelity; Mutations; dNTP pools; Mismatch Repair; Checkpoint; Ribonucleotide Reductase; Msh2; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

   Sammanfattning : In order to build any structure, a good supply of materials, accurate workers and quality control are needed. This is even the case when constructing DNA, the so-called “Code of Life.” For a species to continue to exist, this DNA code must be copied with incredibly high accuracy when each and every cell replicates. LÄS MER

4. 3. The role of RNA-binding motif 3 in epithelial ovarian cancer: A biomarker discovery approach

   Författare :Åsa Ehlén; Malmö Patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA integrity checkpoint; cisplatin treatment; prognostic predictive marker; RBM3; epithelial ovarian cancer; Chk1; Chk2; MCM3;

   Sammanfattning : Epithelial ovarian cancer (EOC) is the most lethal of all gynaecological malignancies and there is an urgent need to develop new prognostic and treatment predictive biomarkers for a more efficient therapy. The discovery of the RNA-binding motif protein 3 (RBM3) as a putative cancer biomarker was based on its differential expression in various cancer forms in the Human Protein Atlas (HPA). LÄS MER

5. 4. Host epithelium integrity in the female reproductive tract during Neisseria gonorrhoeae infection

   Författare :Linda Weyler; Helena Aro; Lene Rasmussen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Female reproductive tract; Neisseria gonorrhoeae; VK2 E6E7 cells; DNA damage; cell cycle; mitosis; restriction endonucleases; infection models; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Neisseria gonorrhoeae infections are asymptomatic in approximately fifty percent of the affected women. Left untreated, this can develop into a long-term inflammatory state with detrimental secondary complications such as ectopic pregnancy and sterility. Furthermore, studies have shown that N. LÄS MER

7. 5. Regulation of G2 phase and long-term consequences of DNA damage

   Författare :Anna Won Middleton; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cell proliferation requires the accurate replication of DNA and equal segregation of replicated genes, important for maintaining the integrity of newly formed cells. At the centre of this process is a series of coordinated events termed ‘the cell cycle’, which ensures cell proliferation proceeds with high fidelity. LÄS MER