Sökning: "cellular aging"
Visar resultat 6 - 10 av 67 avhandlingar innehållade orden cellular aging.
6. Cellular remodeling in response to nutrient exhaustion : From membrane contact sites to autophagy
Sammanfattning : Adaptation to fluctuating environments is critical for cellular fitness and survival. Cells need to sense changes in their surroundings and quickly adjust cellular homeostasis and metabolism accordingly. LÄS MER
7. The effect of Plasmodium infection on cellular aging in humans
Sammanfattning : Telomeres play an essential role in maintaining chromosomal integrity and stability. Telomere shortening is part of the natural aging process, nevertheless, accelerated telomere shortening has been linked to chronic diseases and premature aging. LÄS MER
8. Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins
Sammanfattning : Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging factors, e.g. damaged and aggregated proteins. LÄS MER
9. Functional analysis of the proteasome in eukaryotic organisms
Sammanfattning : Proteasome degradation machinery is responsible for the turnover of a huge variety of normal and abnormal proteins, thus regulating a plethora of cellular processes. Aging is an inevitable biological process that is characterized by reduced proteasome function that leads to proteotoxic stress. LÄS MER
10. Mechanisms of lipofuscin/ceroid accumulation and its impact on the function of the lysosomal system
Sammanfattning : The accumulation of lipofuscin - an electron-dense, autofluorescent, polymeric, intralysosomal substance - is a recognized hallmark of aging postmitotic cells. Ceroid- a substance very close, or perhaps even identical, to lipofuscin - is a characteristic of various pathological processes, such as lysosomal storage diseases, malnutrition, atherosclerosis, oxidative stress, ionizing radiation, etc. LÄS MER