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Visar resultat 6 - 10 av 20 avhandlingar som matchar ovanstående sökkriterier.

1. 6. New approaches for synthesis and analysis of adducts to N-terminal valine in hemoglobin from isocyanates, aldehydes, methyl vinyl ketone and diepoxybutane

   Författare :Ronnie Davies; Margareta Törnqvist; Leif Kronberg; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbamoylation; modified-Edman procedure; 5- hydroxymethyl furfural; MISPE; biomarkers; Environmental chemistry; Miljökemi; miljökemi; Environmental Chemistry;

   Sammanfattning : Human exposure to harmful compounds in the environment, from intake via food, occupational exposures or other sources, could have health implications. Exposure to reactive compounds/metabolites can be identified and quantified as hemoglobin (Hb) adducts by mass spectrometry. LÄS MER

3. 7. DNA adducts as biomarkers of exposure to some dietary carcinogens

   Författare :Tina Jurén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Humans are exposed to many chemicals via intake of food and drink and there are strong associations between dietary factors and cancer. Exposure to the dietary carcinogens acrylamide and acetaldehyde are potential health risks that have made the headlines. High levels of acrylamide are found in various food items, such as potato chips. LÄS MER

4. 8. Protein Modifications by Low Molecular Weight Chemicals Inducing Airways Diseases

   Författare :Marina Jeppsson; Avdelningen för arbets- och miljömedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MSight; hemoglobin human serum albumin; nasal lavage; acrylates; organic acid anhydrides; persulfate; biomarkers adducts; mass spectrometry; MoDetect;

   Sammanfattning : Airways diseases are one of the most common health effects in the western world today. It has been shown that low molecular weight chemicals (LMWC) can cause airways diseases. The mechanisms for these diseases are not well known in most cases. Also, methods for biological monitoring of exposure are not available for many of these LMWC. LÄS MER

5. 9. Method for measurement of exposure to electrophiles : Strategy for identification and exposure estimation using N-terminal haemoglobin adducts

   Författare :Efstathios Vryonidis; Margareta Törnqvist; Hitesh Motwani; Isabella Karlsson; Marie Pedersen; Gabriele Sabbioni; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Haemoglobin adducts; Electrophilic exposure; LC-MS; Adductomics; Acrylamide; Environmental Sciences; miljövetenskap;

   Sammanfattning : We are exposed to many chemicals in our everyday life. Some of these chemicals could pose risks for our health. To reduce such risks, it is important to know what we are exposed to, how much, and how toxic the chemicals are. LÄS MER

7. 10. Development of an adductomic approach to identify electrophiles in vivo through their hemoglobin adducts

   Författare :Henrik Carlsson; Margareta Törnqvist; Gunnar Boysen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Adductomics; Hemoglobin adducts; LC MS MS; Ethyl vinyl ketone; Glyoxal; Methylglyoxal; Acrylic acid; 1-Octen-3-one; Environmental Chemistry; miljökemi;

   Sammanfattning : Humans are exposed to electrophilically reactive compounds, both formed endogenously and from exogenous exposure. Such compounds could react and form stable reaction products, adducts, at nucleophilic sites in proteins and DNA. LÄS MER