Sökning: "Haemoglobin adducts"

Hittade 5 avhandlingar innehållade orden Haemoglobin adducts.

  1. 1. Method for measurement of exposure to electrophiles : Strategy for identification and exposure estimation using N-terminal haemoglobin adducts

    Författare :Efstathios Vryonidis; Margareta Törnqvist; Hitesh Motwani; Isabella Karlsson; Marie Pedersen; Gabriele Sabbioni; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Haemoglobin adducts; Electrophilic exposure; LC-MS; Adductomics; Acrylamide; Environmental Sciences; miljövetenskap;

    Sammanfattning : We are exposed to many chemicals in our everyday life. Some of these chemicals could pose risks for our health. To reduce such risks, it is important to know what we are exposed to, how much, and how toxic the chemicals are. LÄS MER

  3. 2. Biomarkers of aromatic isocyanates in exposed workers

    Författare :Pernilla Lind; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adducts; biomarkers; exposure; occupational; methylenediphenyl diisocyanate; toluene diisocyanate; amines; isocyanates; polyurethane; Gas chromatography; mass spectrometry; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Sammanfattning : The aromatic isocyanates, toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI), are used in the production of polyurethane (PUR) foams, paints, elastomers and glues. The use of isocyanates is increasing, and exposure to isocyanates is the most common cause of occupational asthma. LÄS MER

  4. 3. Biomarkers of internal exposure/dose : Methods to quantify adducts to protein and DNA by LC/MS studied with benzo[a]pyrene and isocyanates

    Författare :Emelie Westberg; Margareta Törnqvist; Kimmo Peltonen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biomarker; PAH; serum albumin; adduct; DNA; isocyanate; miljökemi; Environmental Chemistry;

    Sammanfattning : This thesis focuses on methods for quantification by liquid chromatography/mass spectrometry (LC/MS) of specific biomarkers for internal dose of chemicals which induce toxicity through their electrophilic reactivity. In vivo such compounds are short-lived, and could feasibly be measured as their reaction products (adducts) with biomacromolecules. LÄS MER

  5. 4. Hemoglobin dosimetry and comparative toxicity of acrylamide and its metabolic glycidamide

    Författare :Emma Bergmark; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : Hemoglobin is a useful in vivo dosimeter for electrophilic compounds that react with nucleophilic sites in macromolecules and form covalently bound adducts. With the purpose of increasing the sensitivity of analysis of haemoglobin adducts, a method was developed for enriching adducted globin chains based on ion-exchange chromatography. LÄS MER

  7. 5. Hairdressers' occupational exposure to carcinogenic aromatic amines

    Författare :Gabriella Åkerman; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The hairdresser occupation is classified as probably carcinogenic to humans based on an excess risk for urinary bladder cancer, but it is unclear if current work as a hairdresser entails such a risk. The overall aim of this thesis was to investigate if hairdressers have an ongoing exposure to selected carcinogenic aromatic amines. LÄS MER