Sökning: "Hitesh Motwani"

Hittade 3 avhandlingar innehållade orden Hitesh Motwani.

  1. 1. Cob(I)alamin as a Quantitative Tool for Analysis, Metabolism and Toxicological Studies of Electrophilic Compounds : Butadiene Epoxides, Glycidamide and Sucralose

    Författare :Hitesh Vijay Motwani; Margareta Törnqvist; Bernard T Golding; Johanna Haglund; Wolfgang Buckel; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; Miljökemi; Environmental Chemistry; miljökemi;

    Sammanfattning : Vitamin B12 can be reduced to cob(I)alamin [Cbl(I)], which is one of the most powerful nucleophiles known and referred to as a “supernucleophile”. Cbl(I) was applied as a tool in toxicological studies of the air pollutant 1,3-butadiene (BD), the toxicant acrylamide (AA) present in many foods, and the artificial sweetener sucralose. LÄS MER

  3. 2. DNA adductomics: Method development and integration in biological effect monitoring

    Författare :Giulia Martella; Elena Gorokhova; Hitesh V. Motwani; Brita Sundelin; Gunnar Boysen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA adducts; Nucleic acids; High-resolution mass spectrometry; Data-independent acquisition; Biological effect monitoring; Environmental contaminants; Biomarkers; Amphipods as sentinel species; Environmental Sciences; miljövetenskap;

    Sammanfattning : Environmental omics can provide informative biomarkers for identifying pathologies or physiological responses to environmental change. Nucleic acid adductomics, one of the newest omics techniques, is particularly well suited for assessing exposure and effects of environmental contaminants because the technique can capture modifications at the (epi)genome level. LÄS MER

  4. 3. Method for measurement of exposure to electrophiles : Strategy for identification and exposure estimation using N-terminal haemoglobin adducts

    Författare :Efstathios Vryonidis; Margareta Törnqvist; Hitesh Motwani; Isabella Karlsson; Marie Pedersen; Gabriele Sabbioni; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Haemoglobin adducts; Electrophilic exposure; LC-MS; Adductomics; Acrylamide; Environmental Sciences; miljövetenskap;

    Sammanfattning : We are exposed to many chemicals in our everyday life. Some of these chemicals could pose risks for our health. To reduce such risks, it is important to know what we are exposed to, how much, and how toxic the chemicals are. LÄS MER