Sökning: "apoptotic regulators"

Visar resultat 11 - 15 av 31 avhandlingar innehållade orden apoptotic regulators.

  1. 11. Characterization of the perturbed differentiation in neuroblastoma, aided by the analysis of normal sympathetic nervous system development

    Författare :Carolina Gestblom; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; development; TrkA; apoptosis; proliferation; sympathetic nervous system; neuronal; paraganglia; neuroblastoma; chromaffin; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Neuroblastoma is a pediatric tumor derived from cells in the sympathetic nervous system. In an attempt to explain the heterogeneous clinical behavior of neuroblastoma tumors, neuroblastomas have been characterized with regard to their degree of sympathetic differentiation. LÄS MER

  3. 12. MicroRNAs : significance for sensitivity/resistance of lung cancer cells to treatment

    Författare :Nadeem Shahzad Akbar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Intrinsic or acquired resistance of lung cancer (LC) to chemo- or radiotherapy (CT/RT) limits the treatment effectiveness, which, in turn contributes to tumor progression and ultimately increases the mortality rate of the LC patients. Although resistance to tumor treatment is a multifactorial event for which several factors were identified, still many critical features underlying the mechanisms of resistance remain elusive. LÄS MER

  4. 13. DNA damage-induced cell death : the role of caspase-2

    Författare :Helin Vakifahmetoglu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Apoptosis; caspase-2; DNA damage; mitotic catastrophe; p53;

    Sammanfattning : Activation of a family of cysteine proteases, called caspases, is an important event during apoptosis. In comparison to other caspases, less is known about regulatory functions of caspase-2. Previous studies from our group established caspase-2 as an essential apical regulator of apoptosis triggered by DNA damage. LÄS MER

  5. 14. Targeting Gb3 and apoptosis-related proteins to overcome cisplatin resistance

    Författare :Andreas Tyler; Kjell Grankvist; Simon Ekman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cisplatin resistance; exosomes; gb3; HSP70; the Bcl-2 family; cell research; cellforskning; Medical Cell Biology; medicinsk cellbiologi; onkologi; Oncology;

    Sammanfattning : Background Cisplatin is used for treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) but treatment with cisplatin often leads to acquired resistance to cisplatin, resulting in poor patient survival. Globotriaosylceramide (Gb3) and multidrug resistance protein 1 (MDR1) have been associated with cisplatin resistance. LÄS MER

  7. 15. 5-Fluorouracil mediated cell death signaling
 in colon carcinoma cells

    Författare :Birce Akpinar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is the third most common form of cancer in the world. 5- Fluorouracil (5-FU) belongs to the fluoropyrimidine-type of drugs and is commonly used in the treatment of several solid tumors. It has become the mainstay of CRC treatment at stage III and high risk stage II, either alone or in combination with other drugs. LÄS MER