Sökning: "apoptotic regulators"

Visar resultat 21 - 25 av 31 avhandlingar innehållade orden apoptotic regulators.

  1. 21. Characterization and environmental influences on inflammatory and physiological responses

    Författare :Hazem Khalaf; Per-Erik Olsson; Joe de Pierre; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inflammation; NF-κB; cytokines; pharmaceuticals; zebrafish; Biology; Biologi; NATURAL SCIENCES; NATURVETENSKAP; Biology; Biologi;

    Sammanfattning : Pharmaceuticals are regularly released into the environment, in particular nonsteroidalanti-inflammatory drugs (NSAIDs) and antibiotics. The measuredconcentrations are relatively low and have therefore been considered to be harmless. LÄS MER

  3. 22. Molecular signatures of progression and chemoresistance in epithelial ovarian carcinoma

    Författare :My Björklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epithelial ovarian carcinoma (EOC) is a heterogeneous disease generally classified into five histopathological subtypes; low- and high-grade serous, endometrioid, clear cell and mucinous carcinomas. Although each subtype has distinct clinical and molecular characteristics, they are all treated with surgery and platinum/ taxane chemotherapy. LÄS MER

  4. 23. Innate immunity in diabetes mellitus. Complement components C4BP and C3 promote survival of β cells under metabolic challenges

    Författare :Klaudia Kulak; Malmö Proteinkemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement System; Inflammasome; Islet Amyloid Polypeptide; Complement C3; C4b-binding protein C4BP ; Interleukin 1β; Autophagy-Related Protein 16 like 1; Diabetes mellitus; type 2;

    Sammanfattning : The Complement system is a main effector mechanism of the innate immune system, acting to enhance clearance of pathogens, but also aids removal of biological debris from the body, including immunocomplexes, apoptotic/necrotic cells and protein aggregates. Complement regulators serve to prevent excessive inflammation and their interaction with the same materials targeted by the complement system results in ‘silent’ cleaning of wastes. LÄS MER

  5. 24. Mitochondria targeting and its consequences for cell death in neuroblastoma

    Författare :Kadri Valter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mitochondria are one of the central regulators of several physiological and pathological processes. For instance, homeostatic glycolysis, citric acid cycle, and oxidative phosphorylation are all regulated by mitochondria. In addition, these organelles play a pivotal role in apoptosis, a process of programmed cell death. LÄS MER

  7. 25. Predictive and prognostic factors of epithelial ovarian cancer and pseudomyxoma peritonei

    Författare :Kathrine Bjersand; Inger Sundström Poromaa; Pernilla Dahm Kähler; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : The overall aim of my thesis was to investigate potential prognostic and predictive factors associated with the tumor cells of epithelial ovarian cancer (EOC) and the gastrointestinal tumor pseudomyxoma peritonei (PMP) to improve and individualize cancer therapy. Both PMP and EOC can develop into peritoneal carcinomatosis (PC), which is characterized by widespread metastasis of cancer tumors in the peritoneal cavity. LÄS MER