Sökning: "TrkA"
Visar resultat 1 - 5 av 35 avhandlingar innehållade ordet TrkA.
1. Neuroblastoma Cell Differentiation: The Role of Neurotrophin Receptor Signaling and N-myc Expression
Sammanfattning : Neuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. LÄS MER
2. Characterization of the perturbed differentiation in neuroblastoma, aided by the analysis of normal sympathetic nervous system development
Sammanfattning : Neuroblastoma is a pediatric tumor derived from cells in the sympathetic nervous system. In an attempt to explain the heterogeneous clinical behavior of neuroblastoma tumors, neuroblastomas have been characterized with regard to their degree of sympathetic differentiation. LÄS MER
3. Why Is It So Hard to Kill a Mast Cell?A Study of Mast Cell Activation and Survival
Sammanfattning : Mast cells have a long life in tissues, where they are involved in inflammatory and hypersensitivity reactions. Activation through cross-linking of the high-affinity IgE-receptor (FcεRI) is a primary stimulus capable of degranulating mast cells, contributing to symptoms of allergy. LÄS MER
4. PACAP in adult sensory neurons - implications in injury and pain
Sammanfattning : The data presented in this thesis deal with the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in adult sensory neurons. We have used different injury and pain models to determine the involvement of PACAP during such conditions. The role of neurotrophins for PACAP expression was also investigated. LÄS MER
5. Changes in human uterine innervation in term pregnancy and labor occurence and roles of neurotrophins and TRPV1
Sammanfattning : Objective: Cervical ripening, is a prerequisite for successful labor, which is often very painful and involves an inflammatory reaction. However, little is presently known con-cerning nerve-related changes in the human uterus during labor and the fundamental hy-pothesis tested here was that labor pain emanates primarily from the cervix uteri. LÄS MER