Sökning: "amyloid β-peptide"
Visar resultat 26 - 30 av 37 avhandlingar innehållade orden amyloid β-peptide.
26. Cellular and network mechanisms in neurodegenerative disorders : neurotoxicity and rescue strategies
Sammanfattning : The brain can be described as a complex network and its functioning depends on an efficient communication between all its components. Large-scale communication is made possible by neuronal-network oscillations. LÄS MER
27. Design and Synthesis of BACE-1 Inhibitors : Novel Compounds Targeting an Aspartic Protease Important in the Pathogenesis of Alzheimer’s Disease
Sammanfattning : This thesis deals with the design and synthesis of protease inhibitors targeting the aspartic protease BACE-1 (β-site APP cleaving enzyme-1), an enzyme important in the pathogenesis of Alzheimer’s disease. The inhibitors are evaluated with respect to inhibition data, in a structure-activity relationship part. LÄS MER
28. PresequenceProtease (PreP), a novel Peptidasome in Mitochondria and Chloroplasts : Localization, Function, Structure and Mechanism of Proteolysis
Sammanfattning : The information for mitochondrial and chloroplastic protein import and targeting generally resides in the N-terminal part of the protein, called a targeting peptide. The targeting peptide is cleaved off by the organellar processing peptidases after import of a precursor protein. LÄS MER
29. Genetic code expansion in neurons for studying pathogenic mechanisms of Alzheimer disease
Sammanfattning : Every three seconds a new patient is diagnosed with Alzheimer disease (AD). The primary risk factor for this irreversible, progressive brain disorder is old age. It is a growing health concern, not only for the patients, but also for their relatives and society, because the number of affected people is expected to double every 20 years. LÄS MER
30. The functional organization of nuclear membrane proteins and development of new technology for studies of cell signaling
Sammanfattning : The eukaryotic cell is defined by the nucleus, which is delimited by a double membrane structure termed the nuclear envelope (NE). The NE is implicated in a multitude of different processes, for example chromatin organization. LÄS MER
