Sökning: "amyloid β-peptide"

Visar resultat 31 - 35 av 37 avhandlingar innehållade orden amyloid β-peptide.

  1. 31. The interplay between mitochondria-endoplasmic reticulum contacts and Alzheimer’s disease

    Författare :Nuno João Santos Leal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Even though Alzheimer’s disease (AD) was first described more than 100 years ago, we still have no treatment preventing the ongoing neurodegenerative process. Two major pathological hallmarks have been connected to AD: extracellular amyloid plaques (constituted by amyloid β-peptide – Aβ) and neurofibrillary tangles. LÄS MER

  3. 32. Mitochondria in Alzheimer's Disease : The Presequence Protease and Mitochondria-Associated ER Membranes

    Författare :Catarina Moreira Pinho; Elzbieta Glaser; Paolo Bernardi; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s Disease; Mitochondria; Mitochondria-associated ER membranes; human Presequence Protease; Biochemistry; biokemi;

    Sammanfattning : Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative disorders and the accumulation of the amyloid-β peptide (Aβ) in the temporal lobe has been implicated in the pathology of AD. Synaptic transmission in neuronal cells is a highly energy dependent process, which relies on the presence and proper function of mitochondria. LÄS MER

  4. 33. Molecular studies of the γ-secretase complex : focus on genetic and pharmacological modulation

    Författare :Johanna Wanngren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : γ-Secretase is a multi-subunit protease complex, composed of presenilin (PS1 or PS2), Nicastrin, Pen-2 and Aph-1, which generates the Alzheimer disease (AD) related 30-43 amino acid long amyloid β-peptide (Aβ). The complex is also crucial for important cell signaling, such as the Notch receptor pathway. LÄS MER

  5. 34. Mitochondria in Alzheimer disease : regulatory mechanisms and cell death

    Författare :Louise Hedskog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Synaptic loss is the major correlate for cognitive decline in Alzheimer disease (AD). Processes taking place in the synapses are highly energy demanding and needs strict regulation, which makes the mitochondria and ER crucial at these sites so as to supply energy and spatially regulate intracellular calcium signaling. LÄS MER

  7. 35. Different types of γ-secretes complexes and their effect on substrate processing

    Författare :Annelie Pamrén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The γ-secretase complex is a transmembrane aspartyl protease that generates the Alzheimer disease (AD) related amyloid β-peptide (Aβ) from the amyloid precursor protein (APP). The γ-secretase complex cleaves APP at two different sites (γ- and ε-sites) generating Aβ-peptides and the APP intracellular domain (AICD). LÄS MER