Sökning: "VEGFR2"

Visar resultat 6 - 10 av 39 avhandlingar innehållade ordet VEGFR2.

  1. 6. Biological consequences of endothelial cell signaling

    Författare :Ross Smith; Lena Claesson-Welsh; Przemyslaw Sapieha; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; VEGFR2; Mechanosensing; Retinopathy; Biologi; Biology;

    Sammanfattning : Endothelial cells make up the inner lining of blood and lymphatic vessels, where they participate in functions vital to survival of the tissue; endothelial cells maintain vessel integrity, dynamically respond to the changing metabolic needs of tissues, and participate in many tissue-specific functions. Endothelial cells sense environmental cues which initiate signal transduction pathways that regulate behavior. LÄS MER

  3. 7. Directing Angiogenesis : Cellular Responses to Gradients in vitro

    Författare :Irmeli Barkefors; Johan Kreuger; Lena Kjellén; Pär Gerwins; Ferdinand Le Noble; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Angiogenesis; Endothelial cell; Cell migration; Chemotaxis; Gradients; Microfluidics; VEGFA; VEGFR2; Exocyst; Exocytosis; Cell and molecular biology; Cell- och molekylärbiologi; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Blood vessels are essential for the delivery of nutrients and oxygen to tissues, as well as for the removal of waste products. Patients with tumors, wounds or diabetes all have active angiogenesis, formation and remodeling of blood vessels, a process that is initiated and manipulated by gradients of secreted signaling proteins. LÄS MER

  4. 8. Targeting EGFR and VEGFR2 tyrosine kinases with positron emission tomography : evaluation of two radiotracers

    Författare :Erik Samén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Receptor tyrosine kinases (RTKs) are commonly involved in the development, growth and spread of cancer. Targeted therapy with tyrosine kinase inhibitors (TKIs) has proven a successful treatment strategy against cancers in which growth is dependent on the expression of these receptors. LÄS MER

  5. 9. Tamoxifen response in primary breast cancer with special reference to tumour-specific VEGF-A and VEGFR2

    Författare :Lisa Rydén; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; oncology; cancerology; Cytologi; onkologi; cancer; prognosis; randomised controlled trial; adjuvant tamoxifen treatment; vascular endothelial growth factor receptor 2; breast cancer; vascular endothelial growth factor A;

    Sammanfattning : Background: Treatment of primary breast cancer is individualised and adjuvant systemic treatment is delivered to most patients after surgery. Oestrogen receptor (ER) status and progesterone receptor status (PR) can define patients who would benefit from adjuvant endocrine therapy with tamoxifen (TAM) alone or as chemo-endocrine therapy. LÄS MER

  7. 10. On VEGF and related factors in neurotrauma

    Författare :Mattias Sköld; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Spinal cord; brain; motoneuron; VEGF; VEGFR1; VEGFR2; Np1; Np2; Sema3A; HIF1alpha;

    Sammanfattning : At present, there is no cure for traumatic spinal cord and brain injuries. Therapies in use have only modest effect on outcome. Therefore, the need to better understand the biology of traumatic CNS injuries, making development of new therapies possible, is huge. LÄS MER