Sökning: "VEGFA"

Visar resultat 1 - 5 av 22 avhandlingar innehållade ordet VEGFA.

  1. 1. THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate

    Författare :Matilda Rehn; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic Stem Cells; Stem Cell Niche; Hypoxia; Hypoxia-Inducible Factor; Vegfa.;

    Sammanfattning : Hematopoiesis is the process of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. LÄS MER

  3. 2. Directing Angiogenesis : Cellular Responses to Gradients in vitro

    Författare :Irmeli Barkefors; Johan Kreuger; Lena Kjellén; Pär Gerwins; Ferdinand Le Noble; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Angiogenesis; Endothelial cell; Cell migration; Chemotaxis; Gradients; Microfluidics; VEGFA; VEGFR2; Exocyst; Exocytosis; Cell and molecular biology; Cell- och molekylärbiologi; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Blood vessels are essential for the delivery of nutrients and oxygen to tissues, as well as for the removal of waste products. Patients with tumors, wounds or diabetes all have active angiogenesis, formation and remodeling of blood vessels, a process that is initiated and manipulated by gradients of secreted signaling proteins. LÄS MER

  4. 3. Responses to Tumour initiating factors and Regulation of Normal and Malignant Haematopoiesis

    Författare :Eva Diffner; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The haematopoietic stem cell (HSC) resides within a specific environment enabling it to retain its self-renewal capacity or quiescent state. It is proposed that the HSC niche is hypoxic, a milieu within which the HSC is protected from intrinsic and extrinsic stimuli. LÄS MER

  5. 4. The role of HIF-1alpha in epigenetic regulation of transcription

    Författare :Nikola Vojnovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The oxygen level inside cells, determine the amount of HIF protein. By directly being involved in HIF protein turnover rates, through a mechanism, by which, oxygen is utilized as a co-factor, for the PHD enzymes, regulating HIF protein stability. LÄS MER

  7. 5. Relation between nutritional status, the outcome of infection and immune responses

    Författare :Graciela Terán; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A causal interaction between nutrition and the outcome of different infections has been known since long time ago. Moreover, responses of human beings to infection are diverse and demarcated by immunity. A deficient and unappropriated nutrition allows to a deficient immune response. LÄS MER