Sökning: "Translation initiation region"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden Translation initiation region.

1. 1. Structural and Genetic Studies of Translation in Escherichia coli

   Författare :Qing Zhao; Leif Isaksson; Lars-Göran Öfverstedt; Odd Nygård; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; electron tomography; ribosome; 30S subunit; 50S subunit; rifampicin; Escherichia coli; Translation initiation; Initiation codon; Downstream Region DR ; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar;

   Sammanfattning : Ribosomes are the universal ribonucleoprotein organelles that translate the genetic message from mRNA to protein. In prokaryotes, the ribosomal subunits are 30S and 50S subunit, which bind together during the translation process forming 70S ribosome. LÄS MER

3. 2. Studies on Translation Initiation and trans-Translation

   Författare :Serhiy Surkov; Leif Isaksson; Udo Bläsi; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; E. coli; ribosome; IF1; tmRNA; trans-translaton; Molecular biology; Molekylärbiologi; molekylärgenetik; Molecular Genetics;

   Sammanfattning :  Translation initiation factor 1 (IF1) is an essential bacterial protein, without any clearly defined function in translation initiation. Same point mutants in this protein exhibit cold-sensitivity. In addition, a sequence specific increase in test protein expression has been observed for these mutants. LÄS MER

4. 3. Studies on translation initiation and gene expression in Escherichia coli

   Författare :Ernesto I. Gonzalez de Valdivia; Leif Isaksson; Stephen Douthwaite; Stockholms universitet; []
   Nyckelord :Downstream region; NGG codons; abortive translation; drop-off; Shine-Dalgarno sequence; gene expression and Escherichia coli; NATURAL SCIENCES; NATURVETENSKAP;

   Sammanfattning : In prokaryotes, several mRNA sequences surrounding the initiation codon have been found to influence the translation process; these include the downstream region and its codon context, the Shine-Dalgarno sequence and the S1 ribosomal protein-binding site. In this thesis, the purpose has been to study the role of the downstream region and Shine-Dalgarno-like sequences on early translation elongation and gene expression in Escherichia coli. LÄS MER

5. 4. Role of the 3'UTR in translation and stability of HCV and HPV mRNAs

   Författare :Lisa Wiklund; Laszlo Szekely; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Hepatitis C virus; Human Papillomavirus; 3’ untranslated region; AU-rich sequence; mRNA stability; translation; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

   Sammanfattning : Virus mRNAs can be divided into functional regions. The focus of this thesis will be to investigate the function of one of these regions, the 3’ untranslated region (UTR). The 3’UTR of HCV contains a U-rich element and the late 3’UTR of HPV-1 contains an AU-rich element. LÄS MER

7. 5. Ribosome standby sites and other structural aspects of translation initiation regions in Escherichia coli

   Författare :Maaike M. Sterk; Gerhart E. H. Wagner; Fredrik Söderbom; Isabella Moll; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome standby sites; translation initiation; mRNA structure; bacteria;

   Sammanfattning : Translation initiation, which is rate-limiting in protein synthesis, is often the step at which regulation occurs. Here, we investigated several mechanisms of translation initiation in Escherichia coli, including their control. LÄS MER