Sökning: "Thymidine kinase"

Visar resultat 11 - 15 av 39 avhandlingar innehållade orden Thymidine kinase.

  1. 11. Targets and strategies for drug development against human African sleeping sickness

    Författare :Farahnaz Ranjbarian; Anders Hofer; Staffan G. Svärd; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T. brucei thymidine kinase; T. brucei methylthioadenosine phosphorylase; FANA-A purine nucleoside analogues; essential oils;

    Sammanfattning : Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. LÄS MER

  3. 12. Nucleoside analog toxicity and nucleoside kinase deficiency : effects on mitochondrial DNA

    Författare :Mia Bjerke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nucleoside analogs are modified nucleosides used in treatment of cancer and viral infections. They are dependent on intracellular phosphorylation to be pharmacologically active. Deoxyribonucleoside kinases catalyze the rate-limiting step in the phosphorylation of many clinically used nucleoside analogs. LÄS MER

  4. 13. Protein tyrosine kinases in insulin producing cells : Expression and putative importance for beta-cell function

    Författare :Charlotte Öberg-Welsh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Protein tyrosine kinase; insulin producing cells; fetal development; VEGF; Src-family; Bsk; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Protein tyrosine kinases are of importance for cell replication and differentiation in manysystems. The mechanisms controlling the replication and differentiation of insulin producingcells are unknown. LÄS MER

  5. 14. Cloning and characterization of human deoxyribonucleoside kinases : phosphorylation of anti-cancer and anti-viral nucleoside analogs

    Författare :Magnus Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :deoxyribonucleoside kinase; nucleoside analog; deoxycytidinekinase; deoxyguanosine kinase; thymidine kinase 1; thymidine kinase 2; deoxyribonucleosidephosphorylation; deoxyribonucleotides; anticancer therapy; antiviral therapy;

    Sammanfattning : Deoxyribonucleoside kinases catalyze the phosphorylation of deoxyribonucleosides to deoxyribonucleoside monophosphates. There are four major deoxyribonucleoside kinasesin human cells: thymidine kinase 1 (TKl), deoxycytidine kinase (dCK), deoxyguanosinekinase (dGK), and thymidine kinase 2 (TK2). LÄS MER

  7. 15. Evaluation of the deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) as a suicide gene for treatment of solid tumors

    Författare :Xinyu Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nucleoside kinases from several species are investigated as "suicide genes" for treatment of malignant tumors. The transfer of the gene encoding herpes simplex virus type-1 thymidine kinase (HSV-1 TK) into malignant cells and subsequent treatment with ganciclovir is one of the most commonly studied strategies of suicide gene therapy. LÄS MER