Sökning: "Thymidine kinase"

Visar resultat 16 - 20 av 39 avhandlingar innehållade orden Thymidine kinase.

  1. 16. Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect

    Författare :Alexandra Treschow; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gene therapy; cell selection; suicide gene; cancer; immunotherapy; viral vectors; thymidine kinase; Na ; K -ATPase;

    Sammanfattning : For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to be developed. Transplant-related morbidity and mortality are severe complications arising from this treatment modality. LÄS MER

  3. 17. Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models

    Författare :Thomas Asklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glioma; gap junction; Cx43; bystander effect; HSV-tk; HDAC inhibitor; tyrosine kinase inhibitor;

    Sammanfattning : The group of patients suffering from the malignant brain tumour glioblastoma multiforme (GBM) have a median survival of only about one year. Thus, new treatment strategies are urgently needed. Gap junctions are intercellular channels, permitting intercellular transfer of water soluble substances. LÄS MER

  4. 18. Quantitative cellular methods in the evaluation of prostate cancer

    Författare :Naining Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :prostate cancer; histopathology; nuclear morphology; DNA ploidy; S-phase fraction; thymidine kinas; Ki-67; cell proliferation; fluorescence cytometry; tissue PSA; prognosis;

    Sammanfattning : The distinction between those prostate cancers rapidly progressing and leading to death and those with little likelihood of causing death in cancer is a major goal in current prostate cancer research. Morphological tumor characteristics at present are the basis for evaluation of the prognosis of the disease. LÄS MER

  5. 19. The Structure-Function Relationship and Evolution of Deoxyribonucleoside Kinases

    Författare :Zeeshan Mutahir; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The synthesis of deoxyribonucleoside triphosphates (dNTPs), building blocks of DNA, can be achieved by two different pathways in the cell. One is called de novo synthesis and the other is known as salvage pathway. The de novo pathway involves synthesis of dNTPs by utilizing basic molecules like sugars, amino acids, CO2, NH3, etc. LÄS MER

  7. 20. Identification and characterization of nucleoside and nucleotide kinases : pharmacological activation of anti-cancer and anti-viral nucleoside analogs

    Författare :An R Van Rompay; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cells require deoxyribonucleotides to synthesize DNA. Structurally modified precursors of deoxyribonucleotides, i.e. nucleoside analogs, are used as anti-viral and anti-cancer compounds. LÄS MER