Sökning: "Thioglycosides"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Thioglycosides.

  1. 1. Synthesis of Orthogonally Functionalized Oligosaccharides for Self-assembled Monolayers and as Multimodal Tools in Chemical Biology

    Författare :Timmy Fyrner; Peter Konradsson; Stefan Svensson; Bo Liedberg; Ulf Ellervik; Linköpings universitet; []
    Nyckelord :Oligosaccharide synthesis; glycosylation; thioglycosides; orthogonally protected; oligo lactosides ; spacer molecule; heterobifunctional; surface plasmon resonance; lipid anchor; self-assembled monolayers; glyconanoparticles;

    Sammanfattning : This thesis covers different topics in the field of synthetic organic chemistry combined with the field of surface science and glycobiology.First, the text presents a series of orthogonally protected oligosaccharides (tri-, penta-, and heptasaccharides) of varying length and structures, which are synthesized with the aim of developing novel heterobifunctional biocompatible cross-linkers. LÄS MER

  3. 2. Development of strategies for construction of thioglycoside building blocks corresponding to repeating triads of Cryptococcus neoformans GXM capsular polysaccharide

    Författare :Lina Rydner; Stefan Oscarson; Olof Ramström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Crytococcus neoformans; Capsular polysaccharide; Thioglycosides; Convergent synthesis; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis focuses on the development of methods for synthesis of thioglycoside building blocks corresponding to the repeating units of the capsular polysaccharide (CPS) of Cryptococcus neoformans, an opportunistic fungal pathogen. The building blocks are suitable for construction of large synthetic oligosaccharides related to the native CPS-structures which are to be used in biological studies in order to identify protective epitopes with the aim to develop a glycoconjugate vaccine against C. LÄS MER

  4. 3. Computational analysis of oligosaccharide conformations – methodological development, applied studies, and design of glycomimetics

    Författare :Francesco Strino; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; histo-blood group antigens; Burkholderia cepacia; genetic algorithms; norovirus; selenoglycosides; sugar conformations; thioglycosides; saccharide conformations;

    Sammanfattning : Carbohydrates are the most abundant class of biomolecules. Besides their roles as structural elements and energy storage, they are involved in signaling and recognition processes. Their functions and activities depend on their preferred conformations. LÄS MER

  5. 4. Synthesis of phytoalexin-elicitor active oligosaccharides and stereocontrolled sialylation using thioglycosides

    Författare :Winnie Birberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  7. 5. Synthesis of some oligosaccharide fragments of biological and chemical interest using thioglycosides

    Författare :Christer Hällgren; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis describes the synthesis of oligosaccharide derivatives corresponding to the repeating unit of the O-antigen from two different bacteria, Shigella dysenteriae type 1 and Salmonella thompson serogroup Ci, and fragments thereof. Synthesis of a decasaccharide of chemical interest for studying carbohydrate dynamics in elongated molecules is also described. LÄS MER