Sökning: "TLRs"

Visar resultat 16 - 20 av 50 avhandlingar innehållade ordet TLRs.

  1. 16. Airway hyperresponsiveness and viral recognizing toll-like receptors

    Författare :Magnus Starkhammar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Common colds caused by viruses are, in healthy individuals, usually self-limited and with relatively mild symptoms. In asthmatic individuals, respiratory viruses can burst the defense immune system and trigger asthma exacerbations, including causing airway hyperresponsiveness (AHR). LÄS MER

  3. 17. Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes

    Författare :Sara Tengvall; Göteborgs universitet; []
    Nyckelord :female genital tract immunity; genital herpes; mucosal adjuvant; TLR; MyD88; CpG ODN;

    Sammanfattning : Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are currently available for human use. LÄS MER

  4. 18. Pattern-recognition receptors and neutrophils in cancer inflammation

    Författare :Camilla Rydberg Millrud; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic inflammation, induced by the use of tobacco and alcohol, or caused by infections has long been suggested to constitute a risk factor for head and neck squamous cell carcinoma (HNSCC). The innate immunity is the first line of defense against pathogens, comprising physical and chemical barriers, anti-microbial peptides, pattern-recognition receptors (PRRs) as well as different kinds of cells, including neutrophils. LÄS MER

  5. 19. Polymorphism in pattern recognition receptor genes in pigs

    Författare :Ingrid-Maria Bergman; Inger Edfors; Kristina Nilsson Ekdahl; Kjell Edman; Dag Inge Våge; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : The mammalian immune defense consists of two systems, which are interconnected and co-operate to provide host defense. The innate immune system is always active and detects and responds to non-self without delay. The adaptive immune system has a lag phase, but is more specific and has got a memory. LÄS MER

  7. 20. The role and mechanism of ubiquitin system in innate immune regulation

    Författare :Swarupa Panda; Nelson O. Gekara; Fredrik Elgh; Anna Överby; Geert van Loo; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; The ubiquitin system; Deubiquitinase; MYSM1; Innate immune regulation Toll-like receptor; RIG-l like receptors; Cytoplasmic DNA receptors; NOD-like receptors; Francisella tularensis; Immune subversion; molekylärbiologi; Molecular Biology;

    Sammanfattning : Pattern-recognition receptors (PRRs) include the cell surface or endosomal membrane localized Toll-like receptors (TLRs) and the cytoplasmic PRRs such as RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and cytoplasmic DNA receptors (CDRs). Triggering of PRRs culminates in the transcriptional induction of pro-inflammatory cytokines and type I interferons (IFNs) that coordinate protection against pathogens but require tight control to avert inflammatory diseases. LÄS MER