Sökning: "TLRs"

Visar resultat 11 - 15 av 50 avhandlingar innehållade ordet TLRs.

  1. 11. Toll-like Receptors in Allergic Rhinitis

    Författare :Mattias Fransson; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; poly I:C ; uteroglobin; Toll-like receptors; Medicine human and vertebrates ; Medicin människa och djur ; Otorhinolaryngology; audiology; auditive system and speech; Otorinolaryngologi; audiologi; hörsel- och talorganen; innate immunity; LPS; allergic rhinitis; bone marrow;

    Sammanfattning : Allergic rhinitis is an inflammatory disorder with the characteristic symptoms itching, sneezing, secretion and blockage upon allergen contact. In addition to the local inflammation in the nose, there is a systemic component that influences peripheral blood, bone marrow and lungs. LÄS MER

  3. 12. Innate mechanisms in upper airway inflammation with focus on epithelium and neutrophils

    Författare :Julia Arebro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mucosal inflammation is a key feature in allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP). The traditional idea of the epithelium as a simple barrier and neutrophils as a homogenous cell population, already terminally differentiated, has lately been reconsidered. LÄS MER

  4. 13. Microbial factors and host responses affecting severity of pneumococcal disease and pneumococcal carriage

    Författare :Andreas Sandgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Streptococcus pneumoniae; molecular epidemiology; serotype; clonality; clones; antibiotic resistance; virulence; animal model; mice; innate immunity; Toll-like receptors; MyD88; bioluminescence.;

    Sammanfattning : Streptococcus pneumoniae, also known as the pneumococcus, is a human specific bacterium and causes infections like otitis media, sinusitis, pneumonia, sepsis and meningitis. However, these bacteria are also frequent colonizers of the nasopharynx of healthy individuals, especially children. LÄS MER

  5. 14. Genetic variations in the NALP3 inflammasome: a susceptibility factor for inflammatory diseases

    Författare :Deepti Verma; Peter Söderkvist; Ulf Andersson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammasome; Interleukin-1 beta; NALP3; autoinflammation; Medical genetics; Medicinsk genetik;

    Sammanfattning : Innate immunity has received impressive attention in the past decade owing to the discovery of the Toll like receptors (TLRs) and the NOD-like receptors (NLRs). While the TLRs specialize in fighting microbes at the cell surface, the NLRs complement by detecting and responding to intracellular microbes. LÄS MER

  7. 15. Studies of innate immune stimulation with CpG in HIV infection

    Författare :Salma Nowroozalizadeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Two types of human immunodeficiency virus (HIV) may cause acquired immune deficiency syndrome (AIDS): HIV-1, the most pathogenic virus of the two and found worldwide, and HIV-2, which is mostly detected in West Africa and known to be less transmissible and which demonstrates slower progression towards immunodeficiency. How CD4+ T cells are lost during these two infections is not yet completely clear; however, a constant battle against the rapid viral turnover, resulting in chronic inflammation, is thought to exhaust several compartments of the immune system. LÄS MER