Sökning: "MyD88"

Visar resultat 1 - 5 av 44 avhandlingar innehållade ordet MyD88.

  1. 1. Mechanisms of dendritic cell maturation induced by intracellular bacteria infection

    Författare :Miguel A. Tam; Göteborgs universitet; []
    Nyckelord :Listeria; Salmonella; dendritic cells; maturation; MyD88; IFN-? ?;

    Sammanfattning : Dendritic cells (DCs) are essential for the development of an immune response against pathogens such as Listeria monocytogenes and Salmonella typhimurium. This is mostly because of their unique capacity to stimulate naïve T cells. LÄS MER

  3. 2. The role of intestinal dendritic cells and the microbiota during oral Salmonella infection

    Författare :Maria Fernández-Santoscoy; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Salmonella; dendritic cells; NK-kB; MyD88; CD40; CD103; IRF4; microbiota;

    Sammanfattning : The intestinal pathogen Salmonella causes millions of infections per year worldwide. The immune response to these bacteria involves interactions between several cell types via specific molecules and is under the influence of the intestinal microbiota. Dendritic cells (DC) initiate immune responses including those to Salmonella. LÄS MER

  4. 3. Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes

    Författare :Sara Tengvall; Göteborgs universitet; []
    Nyckelord :female genital tract immunity; genital herpes; mucosal adjuvant; TLR; MyD88; CpG ODN;

    Sammanfattning : Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are currently available for human use. LÄS MER

  5. 4. Studies of the pathogenesis of Enterohemorrhagic Escherichia coli infections: pathogen virulence factors and host response

    Författare :Carla Calderon Toledo; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; host-pathogen; MyD88; TLRs; LEE; Shiga toxin; HUS; EHEC; EPEC; immune response; virulence factors;

    Sammanfattning : Enterohemorrhagic Escherichia coli (EHEC) is a highly virulent pathogen that can cause diarrhea and a life-threatening disease known as hemolytic uremic syndrome. EHEC possess an array of virulence factors that can exert severe consequences in the host. Shiga toxin constitutes a key virulence factor. LÄS MER

  7. 5. Acute pancreatitis, from local defense to remote organ injury

    Författare :Hamid Akbarshahi; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute pancreatitis; heparan sulfate; damage associated molecular patterns; toll-like receptor4; MyD88; IRF-3; acute lung injury; macrophages; transforming growth factor-beta; Smad;

    Sammanfattning : Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications such as acute lung injury (ALI). LÄS MER